TCN1 binds Cbl in the circulation

Stable Identifier
R-HSA-3245898
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Transcobalamin 1 (TCN1 aka haptocorrin, HC, TCI) is a glycoprotein produced by many cells including gastric cells in response to go food intake (Johnston et al. 1989). It can also bind a large fraction of cobalamin (Cbl) in the general circulation. No functional significance for this general binding is presently known (Quadros 2010, Alpers & Russel-Jones 1999 (in Chemistry and Biochemistry of B12, Banerjee 1999)).

Literature References
PubMed ID Title Journal Year
2777761 Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein

Johnston, J, Bollekens, J, Allen, RH, Berliner, N

J. Biol. Chem. 1989
19832808 Advances in the understanding of cobalamin assimilation and metabolism

Quadros, EV

Br. J. Haematol. 2010
  Chemistry and Biochemistry of B12.

Banerjee, R

  1999
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