Reactome | AKT3 [plasma membrane]

AKT3 [plasma membrane]

Stable Identifier

R-HSA-2976006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RAC-gamma serine/threonine-protein kinase ecNumber2.7.11.1/ecNumber, AKT3_HUMAN

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External Reference Information

External Reference

UniProt:Q9Y243 AKT3

Gene Names

AKT3, PKBG

Chain

initiator methionine:, chain:2-479

Reference Genes

BioGPS Gene:10000 AKT3

COSMIC (genes):AKT3 AKT3

CTD Gene:10000 AKT3

dbSNP Gene:10000 AKT3

ENSEMBL:ENSG00000117020 AKT3

HGNC:393 AKT3

KEGG:hsa:10000 AKT3

Monarch:10000 AKT3

NCBI Gene:10000 AKT3

OMIM:611223 AKT3

UCSC:Q9Y243 AKT3

Reference Transcript

Other Identifiers

10000

11739189_at

11739190_a_at

11739191_at

11758336_s_at

11759289_at

11759290_at

16701238

212607_PM_at

212607_at

212609_PM_s_at

212609_s_at

219393_PM_s_at

219393_s_at

222880_PM_at

222880_at

224229_PM_s_at

224229_s_at

242879_PM_x_at

242879_x_at

2464006

2464007

2464008

2464009

2464010

2464011

2464012

2464013

2464014

2464020

2464026

2464027

2464033

2464035

2464036

2464050

2464051

2464052

2464053

2464059

2464061

2464062

2464063

2464065

2464066

2464067

2464068

2464075

2464077

2464081

2464082

2464105

2464106

2464107

2464112

2464113

2464114

2464116

2464118

2464120

2464135

40781_at

7925531

80409_at

83997_r_at

87279_at

A_23_P160354

A_24_P110983

A_24_P45481

GE537571

GE56492

GE88420

GO:0000002

GO:0001938

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0006468

GO:0007005

GO:0007165

GO:0016020

GO:0016740

GO:0032008

GO:0035556

GO:0043226

GO:0043536

GO:0045766

GO:0045793

GO:0048854

GO:0048873

GO:0090050

GO:0106310

GO:0140096

GO:1905564

GO:1905653

GO:2000773

HMNXSV003005098

HMNXSV003016224

HMNXSV003022774

Hs.161189.0.A1_3p_at

Hs.161189.0.A1_3p_x_at

Hs.300642.0.S1_3p_at

Hs.300642.0.S1_3p_s_at

Hs.300642.0.S2_3p_at

ILMN_1733598

ILMN_1757130

ILMN_2325610

ILMN_2325612

PH_hs_0023601

TC01004040.hg

TC01006240.hg

U79271_at

g4574743_3p_at

g4885548_3p_a_at

g5912042_3p_a_at

Participates

as a candidate of

AKT [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-T305,S472-AKT3 [nucleoplasm]

p-T305,S472-AKT3 [cytosol]

p-S472-AKT3 [plasma membrane]

AKT3 [cytosol]

p-T305-AKT3 [cytosol]

Inferred To

Homologues of AKT3 [plasma membrane] (Dictyostelium discoideum)

Homologues of AKT3 [plasma membrane] (Saccharomyces cerevisiae)

Homologues of AKT3 [plasma membrane] (Schizosaccharomyces pombe)

AKT3 [plasma membrane] (Caenorhabditis elegans)

AKT3 [plasma membrane] (Danio rerio)

AKT3 [plasma membrane] (Dictyostelium discoideum)

AKT3 [plasma membrane] (Drosophila melanogaster)

AKT3 [plasma membrane] (Mus musculus)

AKT3 [plasma membrane] (Rattus norvegicus)

AKT3 [plasma membrane] (Saccharomyces cerevisiae)

AKT3 [plasma membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_859029.1, NP_005456.1, XP_005273051.1, XP_005273052.1, NP_001193658.1

ZINC - World Drugs

AKT3_HUMAN

Guide to Pharmacology - Targets

2286

OpenTargets

ENSG00000117020

ENSEMBL

ENST00000673466, ENSP00000479922, ENSP00000505276, ENST00000263826, ENST00000366540, ENST00000619536, ENSP00000483054, ENSP00000355498, ENST00000613395, ENSP00000263826, ENSP00000500582, ENST00000336199, ENSP00000336943, ENSP00000479081, ENST00000621586, ENST00000680118

ZINC - FDA approved

AKT3_HUMAN

ZINC - Substances

AKT3_HUMAN

ZINC - Biogenic

AKT3_HUMAN

ZINC target

Q9Y243

PRO

Q9Y243

GlyGen

Q9Y243

PDB

2X18

ZINC - Investigational

AKT3_HUMAN

HPA

ENSG00000117020-AKT3

Pharos - Targets

Q9Y243

Orphanet

AKT3

ZINC - Predictions - Purchasable

AKT3_HUMAN

HMDB Protein

HMDBP01363

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.688	5
UniProt:P42574 CASP3	5	CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.571	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.564	4
UniProt:P53804 TTC3			0.524	2