Reactome | Exocyst complex formation

Exocyst complex formation

Stable Identifier

R-HSA-265177

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, secretory granule membrane

ReviewStatus

5/5

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A beta cell contains about 10 000 secretory granules. Of these, about 1000 are docked at the inner surface of the plasma membrane and a subset of about 100 docked granules form the "readily releasable" pool (granules which are released within about 5 minutes of glucose stimulation). As inferred from rat MIN6 cells, docking occurs by interaction between EXOC3/Sec6 located on the membrane of the secretory granule and EXOC4/Sec8 located at the plasma membrane (Tsuboi et al. 2005). Additional components (EXOC1, EXOC2, EXOC5, EXOC6, EXOC7, EXOC8) form the Exocyst Complex. EXOC7 binds the plasma membrane (Matern et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
15878854	Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis Tsuboi, T, Ravier, MA, Xie, H, Ewart, MA, Gould, GW, Baldwin, SA, Rutter, GA	J Biol Chem	2005
11493706	The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells Matern, HT, Yeaman, C, Nelson, WJ, Scheller, RH	Proc Natl Acad Sci U S A	2001
16714477	Insulin vesicle release: walk, kiss, pause ... then run Rutter, GA, Hill, EV	Physiology (Bethesda)	2006