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6xHC-MSR1 [endocytic vesicle membrane]
Stable Identifier
R-HSA-2507846
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endocytic vesicle membrane
Synonyms
MSR1, Macrophage scavenger receptor types I and II, MSRE_HUMAN, SCARA1, SR-AI
Icon
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging by Class A Receptors (Homo sapiens)
MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Homo sapiens)
MSR1:Ligand [endocytic vesicle membrane] (Homo sapiens)
MSR1 (SCARA1) trimer [endocytic vesicle membrane] (Homo sapiens)
6xHC-MSR1 [endocytic vesicle membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
8900177
Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain
Slayter, H
,
Resnick, D
,
Krieger, M
,
Schwartz, K
,
Chatterton, JE
J Biol Chem
1996
External Reference Information
External Reference
UniProt:P21757 MSR1
Gene Names
MSR1, SCARA1
Chain
chain:1-451
Reference Genes
BioGPS Gene:4481 MSR1
COSMIC (genes):MSR1 MSR1
CTD Gene:4481 MSR1
dbSNP Gene:4481 MSR1
ENSEMBL:ENSG00000038945 MSR1
HGNC:7376 MSR1
KEGG:hsa:4481 MSR1
Monarch:4481 MSR1
NCBI Gene:4481 MSR1
OMIM:153622 MSR1
UCSC:P21757 MSR1
Reference Transcript
RefSeq:NM_138715.2 MSR1
RefSeq:NM_002445.3 MSR1
RefSeq:NM_138716.2 MSR1
Other Identifiers
11737428_a_at
11737429_x_at
11737430_a_at
11739845_a_at
11739846_a_at
11739847_x_at
11749847_a_at
11750778_a_at
11756089_s_at
208422_PM_at
208422_at
208423_PM_s_at
208423_s_at
211887_PM_x_at
211887_x_at
214770_PM_at
214770_at
3125584
3125585
3125587
3125588
3125594
3125595
3125596
3125597
3125598
3125600
3125601
3125603
3125605
3125606
3125607
3125609
3125610
3125611
3125612
3125614
3125616
3125617
3125619
3125620
3125636
3125638
3125653
3125657
3125658
3125659
39981_at
39982_r_at
4481
8149448
A_19_P00317971
A_19_P00319993
A_19_P00319994
A_19_P00319995
A_21_P0005802
A_21_P0005803
A_23_P216176
A_23_P392942
A_24_P372223
A_33_P3379326
D13264_at
GE498947
GE57055
GE81154
GO:0001540
GO:0005044
GO:0005515
GO:0005581
GO:0005886
GO:0006897
GO:0006898
GO:0006911
GO:0010629
GO:0010744
GO:0010886
GO:0016020
GO:0016192
GO:0030169
GO:0030301
GO:0030666
GO:0034362
GO:0034381
GO:0038024
GO:0042953
GO:0051649
GO:0061024
GO:0071407
GO:0097242
HMNXSV003006083
HMNXSV003019784
HMNXSV003039111
HMNXSV003055649
Hs.49.2.S1_3p_at
ILMN_1694400
ILMN_1704143
ILMN_1743301
ILMN_2373285
PH_hs_0020601
TC08002237.hg
TC08002238.hg
TC08002239.hg
g3004959_3p_a_at
g3004959_3p_x_at
g4505258_3p_at
p23925
p23926
Participates
as a component of
MSR1 (SCARA1) trimer [endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
6xHC-MSR1 [plasma membrane]
Inferred To
Msr1 [endocytic vesicle membrane]
(Mus musculus)
Msr1 [endocytic vesicle membrane]
(Rattus norvegicus)
MSR1 [endocytic vesicle membrane]
(Canis familiaris)
6xHC-MSR1 [endocytic vesicle membrane]
(Gallus gallus)
6xHC-MSR1 [endocytic vesicle membrane]
(Sus scrofa)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 375 and 439
Coordinate
375
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Intra-chain Crosslink via L-cystine (cross-link) at 388 and 449
Coordinate
388
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Intra-chain Crosslink via L-cystine (cross-link) at 419 and 429
Coordinate
419
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
ENSEMBL
ENSP00000262101
,
ENSP00000262100
,
ENST00000381998
,
ENSP00000347430
,
ENST00000350896
,
ENST00000355282
,
ENSP00000371428
,
ENST00000262101
OpenTargets
ENSG00000038945
HPA
ENSG00000038945-MSR1
ZINC - Substances
MSRE_HUMAN
ZINC target
P21757
PRO
P21757
Pharos - Targets
P21757
GlyGen
P21757
Orphanet
MSR1
ZINC - Predictions - Purchasable
MSRE_HUMAN
PDB
7DPX
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27449 ATP6V0C
7
ATP6V0C [endosome membrane]
(R-HSA-912591)
ATP6V0C [phagocytic vesicle membrane]
(R-HSA-1222603)
ATP6V0C [ficolin-1-rich granule membrane]
(R-HSA-6800908)
ATP6V0C [plasma membrane]
(R-HSA-6806254)
ATP6V0C [azurophil granule membrane]
(R-HSA-6799363)
ATP6V0C [tertiary granule membrane]
(R-HSA-6800991)
ATP6V0C [lysosomal membrane]
(R-HSA-9640194)
0.718
6
UniProt:Q7L5A8 FA2H
1
FA2H [endoplasmic reticulum membrane]
(R-HSA-5693771)
0.556
3
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