Reactome | 6xHC-MSR1 [plasma membrane]

6xHC-MSR1 [plasma membrane]

Stable Identifier

R-HSA-2173717

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

MSR1, Macrophage scavenger receptor types I and II, MSRE_HUMAN, SCARA1, SR-AI

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Literature References

PubMed ID	Title	Journal	Year
8900177	Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain Slayter, H, Resnick, D, Krieger, M, Schwartz, K, Chatterton, JE	J Biol Chem	1996

External Reference Information

External Reference

UniProt:P21757 MSR1

Gene Names

MSR1, SCARA1

Chain

chain:1-451

Reference Genes

BioGPS Gene:4481 MSR1

COSMIC (genes):MSR1 MSR1

CTD Gene:4481 MSR1

dbSNP Gene:4481 MSR1

ENSEMBL:ENSG00000038945 MSR1

ENSEMBL:ENSG00000038945.15 MSR1

HGNC:7376 MSR1

KEGG Gene (Homo sapiens):4481 MSR1

Monarch:4481 MSR1

NCBI Gene:4481 MSR1

OMIM:153622 MSR1

UCSC:P21757 MSR1

Reference Transcript

Other Identifiers

11737428_a_at

11737429_x_at

11737430_a_at

11739845_a_at

11739846_a_at

11739847_x_at

11749847_a_at

11750778_a_at

11756089_s_at

208422_PM_at

208422_at

208423_PM_s_at

208423_s_at

211887_PM_x_at

211887_x_at

214770_PM_at

214770_at

3125584

3125585

3125587

3125594

3125595

3125596

3125597

3125598

3125600

3125601

3125603

3125605

3125606

3125607

3125609

3125610

3125611

3125612

3125616

3125617

39981_at

39982_r_at

4481

8149448

A_23_P216176

A_23_P392942

A_24_P372223

A_33_P3379326

D13264_at

GE57055

GE81154

GO:0001540

GO:0005044

GO:0005515

GO:0005576

GO:0005581

GO:0005615

GO:0005886

GO:0006897

GO:0006898

GO:0006911

GO:0010629

GO:0010744

GO:0010886

GO:0016020

GO:0016192

GO:0030154

GO:0030169

GO:0030301

GO:0030666

GO:0031410

GO:0034362

GO:0034381

GO:0038024

GO:0042953

GO:0043226

GO:0051649

GO:0061024

GO:0071407

GO:0097242

HMNXSV003006083

HMNXSV003055649

Hs.49.2.S1_3p_at

ILMN_1694400

ILMN_1743301

ILMN_2373285

PH_hs_0020601

TC08002237.hg

g3004959_3p_a_at

g3004959_3p_x_at

g4505258_3p_at

Participates

as a component of

MSR1 (SCARA1) trimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

6xHC-MSR1 [endocytic vesicle membrane]

Inferred To

Msr1 [plasma membrane] (Mus musculus)

Msr1 [plasma membrane] (Rattus norvegicus)

6xHC-MSR1 [plasma membrane] (Canis familiaris)

6xHC-MSR1 [plasma membrane] (Gallus gallus)

scara5 [plasma membrane] (Danio rerio)

MSR1 [plasma membrane] (Sus scrofa)

Modified Residues

Name

Intra-chain Crosslink via L-cystine (cross-link) at 375 and 439

Coordinate

375

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Name

Intra-chain Crosslink via L-cystine (cross-link) at 388 and 449

Coordinate

388

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Name

Intra-chain Crosslink via L-cystine (cross-link) at 419 and 429

Coordinate

419

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

RefSeq

NP_002436.1, NP_619729.1, NP_619730.1

OpenTargets

ENSG00000038945

HPA

ENSG00000038945-MSR1

GeneCards

P21757

ZINC - Substances

MSRE_HUMAN

ZINC target

P21757

Ensembl

ENSP00000371428, ENSP00000347430, ENST00000350896, ENST00000262101, ENSP00000262101, ENSP00000262100, ENSG00000038945, ENST00000355282, ENST00000381998

PRO

P21757

Pharos - Targets

P21757

Orphanet

21078

ZINC - Predictions - Purchasable

MSRE_HUMAN

PDB

7DPX

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3