Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
3x4Hyp-COL4A5(?-1685) [extracellular region]
Stable Identifier
R-HSA-2468212
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
4-hydroxyprolyl collagen alpha-5(IV) chain C-term fragment
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)
Cleaved collagen type IV networks [extracellular region] (Homo sapiens)
Cleaved collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
Cleaved collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
Cleaved tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
Cleaved collagen alpha-5(IV) chains [extracellular region] (Homo sapiens)
3x4Hyp-COL4A5(?-1685) [extracellular region] (Homo sapiens)
Cleaved collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Homo sapiens)
Cleaved tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Homo sapiens)
Cleaved collagen alpha-5(IV) chains [extracellular region] (Homo sapiens)
3x4Hyp-COL4A5(?-1685) [extracellular region] (Homo sapiens)
Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)
Cleaved collagen fibrils [extracellular region] (Homo sapiens)
Cleaved collagen type IV networks [extracellular region] (Homo sapiens)
Cleaved collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
Cleaved collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
Cleaved tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
Cleaved collagen alpha-5(IV) chains [extracellular region] (Homo sapiens)
3x4Hyp-COL4A5(?-1685) [extracellular region] (Homo sapiens)
Cleaved collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Homo sapiens)
Cleaved tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Homo sapiens)
Cleaved collagen alpha-5(IV) chains [extracellular region] (Homo sapiens)
3x4Hyp-COL4A5(?-1685) [extracellular region] (Homo sapiens)
Gelatin degradation by MMP19 (Homo sapiens)
Cleaved collagen fibrils [extracellular region] (Homo sapiens)
Cleaved collagen type IV networks [extracellular region] (Homo sapiens)
Cleaved collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
Cleaved collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
Cleaved tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
Cleaved collagen alpha-5(IV) chains [extracellular region] (Homo sapiens)
3x4Hyp-COL4A5(?-1685) [extracellular region] (Homo sapiens)
Cleaved collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Homo sapiens)
Cleaved tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Homo sapiens)
Cleaved collagen alpha-5(IV) chains [extracellular region] (Homo sapiens)
3x4Hyp-COL4A5(?-1685) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29400 COL4A5
Gene Names
COL4A5
Chain
signal peptide:1-26, chain:27-1685
Reference Genes
BioGPS Gene:1287 COL4A5
COSMIC (genes):COL4A5 COL4A5
CTD Gene:1287 COL4A5
dbSNP Gene:1287 COL4A5
ENSEMBL:ENSG00000188153 COL4A5
HGNC:2207 COL4A5
KEGG:hsa:1287 COL4A5
Monarch:1287 COL4A5
NCBI Gene:1287 COL4A5
OMIM:303630 COL4A5
UCSC:P29400 COL4A5
Reference Transcript
RefSeq:NM_033380.2 COL4A5
RefSeq:NM_000495.4 COL4A5
Participates
as a member of
Cleaved collagen alpha-5(IV) chains [extracellular region] (Homo sapiens)
Other forms of this molecule
3x4Hyp-3Hyp-GlcGalHyl-COL4A5 [endoplasmic reticulum lumen]
GlcGalHyl-COL4A5 [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL4A5 [endoplasmic reticulum lumen]
GalHyl-COL4A5 [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GalHyl-COL4A5 [endoplasmic reticulum lumen]
3x4Hyp-GalHyl-COL4A5 [endoplasmic reticulum lumen]
COL4A5 [endoplasmic reticulum lumen]
3x4Hyp-COL4A5 [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-COL4A5 [endoplasmic reticulum lumen]
3x4Hyp-5Hyl-COL4A5 [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-5Hyl-COL4A5 [endoplasmic reticulum lumen]
5Hyl-COL4A5 [endoplasmic reticulum lumen]
3,4-Hyp 5-sulfiliminyl collagen alpha-5(IV) chain [extracellular region]
3x4Hyp-GalHyl-COL4A5 [extracellular region]
3x4Hyp-3Hyp-COL4A5 [extracellular region]
3x4Hyp-GlcGalHyl-COL4A5 [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL4A5 [extracellular region]
5Hyl-COL4A5 [extracellular region]
3x4Hyp-5Hyl-COL4A5 [extracellular region]
3x4Hyp-COL4A5 [extracellular region]
GlcGalHyl-COL4A5 [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL4A5 [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL4A5 [extracellular region]
COL4A5 [extracellular region]
GalHyl-COL4A5 [extracellular region]
COL4A5(27-?) [extracellular region]
5Hyl-COL4A5(27-?) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL4A5(?-1685) [extracellular region]
3x4Hyp-GalHyl-COL4A5(?-1685) [extracellular region]
3x4Hyp-5Hyl-COL4A5(27-?) [extracellular region]
GlcGalHyl-COL4A5(?-1685) [extracellular region]
3x4Hyp-3Hyp-COL4A5(27-?) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL4A5(?-1685) [extracellular region]
5Hyl-COL4A5(?-1685) [extracellular region]
3x4Hyp-GlcGalHyl-COL4A5(27-?) [extracellular region]
GalHyl-COL4A5(?-1685) [extracellular region]
3x4Hyp-3Hyp-COL4A5(?-1685) [extracellular region]
COL4A5(27-?) [extracellular region]
3x4Hyp-GalHyl-COL4A5(27-?) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL4A5(27-?) [extracellular region]
GalHyl-COL4A5(27-?) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL4A5(27-?) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL4A5(?-1685) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL4A5(27-?) [extracellular region]
3x4Hyp-COL4A5(27-?) [extracellular region]
COL4A5(?-1685) [extracellular region]
3x4Hyp-GlcGalHyl-COL4A5(?-1685) [extracellular region]
3x4Hyp-5Hyl-COL4A5(?-1685) [extracellular region]
GlcGalHyl-COL4A5(27-?) [extracellular region]
4-Hyp 5-sulfiliminyl collagen alpha-5(IV) chain [extracellular region]
5-sulfiliminyl collagen alpha-5(IV) chain [extracellular region]
Inferred To
Col4a5 [extracellular region]
(Mus musculus)
Col4a5 [extracellular region]
(Rattus norvegicus)
COL4A5 [extracellular region]
(Bos taurus)
COL4A5 [extracellular region]
(Canis familiaris)
COL4A5 [extracellular region]
(Sus scrofa)
Modified Residues
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Cross References
OpenTargets
ENSG00000188153
ENSEMBL
ENST00000361603
,
ENSP00000354505
,
ENST00000328300
,
ENSP00000331902
,
ENSG00000188153
GeneCards
COL4A5
HPA
ENSG00000188153-COL4A5
PRO
P29400
Pharos - Targets
P29400
GlyGen
P29400
Orphanet
COL4A5
PDB
5NAZ
,
6WKU
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
