Selenocysteine synthesis

Stable Identifier
R-HSA-2408557
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Selenocysteine synthesis
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Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SEPSECS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).

Literature References
PubMed ID Title Journal Year
19747061 Threading the needle: getting selenocysteine into proteins

Donovan, J, Copeland, PR

Antioxid. Redox Signal. 2010
20623998 Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis

Palioura, S, Herkel, J, Simonovic, M, Lohse, AW, Söll, D

Biol. Chem. 2010
18252769 From one amino acid to another: tRNA-dependent amino acid biosynthesis

Sheppard, K, Yuan, J, Devine, KM, Jester, B, Söll, D, Hohn, MJ

Nucleic Acids Res. 2008
Participants
Events
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as an event of
Event Information
Go Biological Process
selenocysteine metabolic process (0016259)
Orthologous Events
Selenocysteine synthesis (Caenorhabditis elegans)
Selenocysteine synthesis (Danio rerio)
Selenocysteine synthesis (Dictyostelium discoideum)
Selenocysteine synthesis (Drosophila melanogaster)
Selenocysteine synthesis (Mus musculus)
Selenocysteine synthesis (Plasmodium falciparum)
Selenocysteine synthesis (Sus scrofa)
Selenocysteine synthesis (Xenopus tropicalis)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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