AKT phosphorylates IKKalpha

Stable Identifier
R-HSA-198611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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AKT phosphorylates IKKalpha
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AKT mediates IKKalpha (Inhibitor of nuclear factor kappa B kinase subunit alpha) phosphorylation at threonine 23, which is required for NF-kB activation. NF-kB promoted gene transcription enhances neuronal survival.

Literature References
PubMed ID Title Journal Year
10485710 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

Ozes, ON, Mayo, LD, Gustin, JA, Pfeffer, SR, Pfeffer, LM, Donner, DB

Nature 1999
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
protein kinase B signaling (0043491)
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
Physical Entity
p-T,p-S-AKT [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
AKT phosphorylates IKKalpha (Canis familiaris)
AKT phosphorylates IKKalpha (Danio rerio)
AKT phosphorylates IKKalpha (Gallus gallus)
AKT phosphorylates IKKalpha (Mus musculus)
AKT phosphorylates IKKalpha (Rattus norvegicus)
AKT phosphorylates IKKalpha (Sus scrofa)
AKT phosphorylates IKKalpha (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-06-29)