AGRN binds laminins

Stable Identifier
R-NUL-2467092
Type
Reaction [binding]
Species
Mus musculus
Compartment
extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AGRN binds laminins
The N-terminus of the LN form of AGRN binds to the laminin gamma1 subunit (Denzer et al. 1997, Kammerer et al. 1999, Mascarenhas et al. 2003). This may indirectly bind AGRN to integrins on the cell surface (Bezakova & Ruegg 2003).
Literature References
PubMed ID Title Journal Year
9151673 Agrin binds to the nerve-muscle basal lamina via laminin

Denzer, AJ, Brandenberger, R, Gesemann, M, Chiquet, M, Ruegg, MA

J. Cell Biol. 1997
11018052 Agrin isoforms with distinct amino termini: differential expression, localization, and function

Burgess, RW, Skarnes, WC, Sanes, JR

J. Cell Biol. 2000
10581249 Interaction of agrin with laminin requires a coiled-coil conformation of the agrin-binding site within the laminin gamma1 chain

Kammerer, RA, Schulthess, T, Landwehr, R, Schumacher, B, Lustig, A, Yurchenco, PD, Ruegg, MA, Engel, J, Denzer, AJ

EMBO J. 1999
Participants
Input
Output
Orthologous Events
AGRN binds Laminins with gamma-1 subunit (Homo sapiens)
Authored
Jupe, S  (2012-06-22)
Reviewed
Venkatesan, N  (2013-05-21)
Ricard-Blum, S  (2013-05-22)
Created
Jupe, S  (2012-09-12)
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