Reactome | Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP

Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP

Stable Identifier

R-HSA-2393954

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

ADP-ribose + H2O => AMP + D-ribose 5-phosphate (mitochondrial)

ReviewStatus

5/5

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Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP

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Mitochondrial NUDT9 (ADP-ribose pyrophosphatase) catalyzes the hydrolysis of ADP-ribose to form AMP and D-ribose 5-phosphate. The active enzyme is the longer of two isoforms generated by alternative splicing and is a monomer complexed with two magnesium ions (Perraud et al. 2003; Shen et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12427752	NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase Rippe, K, Bessman, MJ, Shen, BW, Stoddard, BL, Dunn, CA, Smith, MK, Scharenberg, AM, Perraud, AL	J. Biol. Chem.	2003
12948489	The crystal structure and mutational analysis of human NUDT9 Shen, BW, Stoddard, BL, Scharenberg, AM, Perraud, AL	J. Mol. Biol.	2003