Active MMP3 can cleave pro-HBEGF to form active HBEGF

Stable Identifier
R-HSA-2179402
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Active MMP3 can cleave pro-HBEGF to form active HBEGF
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Gastrin can induce cleavage of pro-HBEGF via MMP3, releasing mature HBEGF. This event is based on evidence from mouse experiments (Suzuki et al. 1997).
Literature References
PubMed ID Title Journal Year
9395517 Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site

Suzuki, M, Fernandez, CA, Raab, G, Moses, MA, Klagsbrun, M

J Biol Chem 1997
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Catalyst Activity

metalloendopeptidase activity of MMP3(100-477) [extracellular region]

Physical Entity
MMP3(100-477) [extracellular region] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
Active Mmp3 can cleave pro-Hbegf to form active Hbegf (Mus musculus)
Authored
Tripathi, S  (2012-04-04)
Jassal, B  (2012-04-04)
Reviewed
D'Eustachio, P  (2012-04-23)
Created
Jassal, B  (2012-04-04)
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