Active MMP3 can cleave pro-HBEGF to form active HBEGF

Stable Identifier
R-HSA-2179402
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Gastrin can induce cleavage of pro-HBEGF via MMP3, releasing mature HBEGF. This event is based on evidence from mouse experiments (Suzuki et al. 1997).

Literature References
PubMed ID Title Journal Year
9395517 Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site

Suzuki, M, Raab, G, Moses, MA, Fernandez, CA, Klagsbrun, M

J Biol Chem 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MMP3(100-477) [extracellular region]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created