Active Mmp3 can cleave pro-Hbegf to form active Hbegf

Stable Identifier
R-MMU-2203911
Type
Reaction [transition]
Species
Mus musculus
Compartment
extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Active Mmp3 can cleave pro-Hbegf to form active Hbegf
Gastrin can induce cleavage of pro-Hbegf via stromelysin-1 (Mmp3), releasing mature Hbegf (Suzuki et al. 1997).
Literature References
PubMed ID Title Journal Year
9395517 Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site

Suzuki, M, Fernandez, CA, Raab, G, Moses, MA, Klagsbrun, M

J Biol Chem 1997
Participants
Input
Output
Catalyst Activity

metalloendopeptidase activity of Mmp3 [extracellular region]

Physical Entity
Mmp3 [extracellular region] (Mus musculus)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Active MMP3 can cleave pro-HBEGF to form active HBEGF (Homo sapiens)
Authored
Tripathi, S  (2012-04-04)
Jassal, B  (2012-04-04)
Reviewed
D'Eustachio, P  (2012-04-23)
Created
Jassal, B  (2012-04-23)
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