Reactome | carbovir + IMP => carbovir monophosphate + inosine

carbovir + IMP => carbovir monophosphate + inosine

Stable Identifier

R-HSA-2162066

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Conversion of carbovir to carbovir monophosphate

ReviewStatus

5/5

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carbovir + IMP => carbovir monophosphate + inosine

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NT5C2 catalyzes the reaction of carbovir and IMP to form carbovir monophosphate and inosine (Johnson and Fridland 1989; Miller et al. 1992). The enzyme was originally identified as a high-Km soluble 5'-nucleotidase most active on IMP and GMP (Spychala et al. 1988). Its active form is a tetramer (Wallden et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
1383219	Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity Miller, WH, Daluge, SM, Garvey, EP, Hopkins, S, Reardon, JE, Boyd, FL, Miller, RL	J Biol Chem	1992
2549385	Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells Johnson, MA, Fridland, A	Mol Pharmacol	1989
2848805	High Km soluble 5'-nucleotidase from human placenta Spychala, J, Madrid-Marina, V, Fox, IH	J Biol Chem	1988
17405878	Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition Wallden, K, Stenmark, P, Nyman, T, Flodin, S, Graslund, S, Loppnau, P, Bianchi, V, Nordlund, P	J Biol Chem	2007