NT5C2 catalyzes the reaction of carbovir and IMP to form carbovir monophosphate and inosine (Johnson and Fridland 1989; Miller et al. 1992). The enzyme was originally identified as a high-Km soluble 5'-nucleotidase most active on IMP and GMP (Spychala et al. 1988). Its active form is a tetramer (Wallden et al. 2007).
Miller, WH, Boyd, FL, Miller, RL, Hopkins, S, Garvey, EP, Reardon, JE, Daluge, SM
Fridland, A, Johnson, MA
Spychala, J, Fox, IH, Madrid-Marina, V
Bianchi, V, Nordlund, P, Stenmark, P, Flodin, S, Nyman, T, Wallden, K, Loppnau, P, Graslund, S
nucleoside phosphotransferase activity of NT5C2 tetramer [cytosol]
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