carbovir + IMP => carbovir monophosphate + inosine

Stable Identifier
Reaction [transition]
Homo sapiens
Conversion of carbovir to carbovir monophosphate
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NT5C2 catalyzes the reaction of carbovir and IMP to form carbovir monophosphate and inosine (Johnson and Fridland 1989; Miller et al. 1992). The enzyme was originally identified as a high-Km soluble 5'-nucleotidase most active on IMP and GMP (Spychala et al. 1988). Its active form is a tetramer (Wallden et al. 2007).

Literature References
PubMed ID Title Journal Year
1383219 Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity

Miller, WH, Boyd, FL, Miller, RL, Hopkins, S, Garvey, EP, Reardon, JE, Daluge, SM

J Biol Chem 1992
2549385 Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells

Fridland, A, Johnson, MA

Mol Pharmacol 1989
2848805 High Km soluble 5'-nucleotidase from human placenta

Spychala, J, Fox, IH, Madrid-Marina, V

J Biol Chem 1988
17405878 Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition

Bianchi, V, Nordlund, P, Stenmark, P, Flodin, S, Nyman, T, Wallden, K, Loppnau, P, Graslund, S

J Biol Chem 2007
Catalyst Activity

nucleoside phosphotransferase activity of NT5C2 tetramer [cytosol]

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