Abacavir metabolism

Stable Identifier
R-HSA-2161541
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Abacavir metabolism
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Abacavir activation proceeds steps of phosphorylation, deamination to yield carbovir monophosphate, and phosphorylation of the latter compound to yield the triphosphate. In addition, abacavir can be conjugated with glucuronide or oxidized to its 5'-carboxylate derivative, the two major forms in which it is excreted from the body (Yuen et al. 2008).
Literature References
PubMed ID Title Journal Year
18479171 A review of the pharmacokinetics of abacavir

Pakes, GE, Weller, S, Yuen, GJ

Clin Pharmacokinet 2008
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
xenobiotic metabolic process (0006805)
Orthologous Events
Abacavir metabolism (Bos taurus)
Abacavir metabolism (Caenorhabditis elegans)
Abacavir metabolism (Canis familiaris)
Abacavir metabolism (Danio rerio)
Abacavir metabolism (Dictyostelium discoideum)
Abacavir metabolism (Drosophila melanogaster)
Abacavir metabolism (Gallus gallus)
Abacavir metabolism (Mus musculus)
Abacavir metabolism (Rattus norvegicus)
Abacavir metabolism (Saccharomyces cerevisiae)
Abacavir metabolism (Schizosaccharomyces pombe)
Abacavir metabolism (Sus scrofa)
Abacavir metabolism (Xenopus tropicalis)
Authored
D'Eustachio, P  (2012-03-14)
Reviewed
Jassal, B  (2012-03-16)
Created
D'Eustachio, P  (2012-03-14)
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