Reactome | PGD2 is reduced to 11-epi-PGF2a by AKRIC3

PGD2 is reduced to 11-epi-PGF2a by AKRIC3

Stable Identifier

R-HSA-2161614

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

H(+) + NADPH + prostaglandin D2 => 11beta-prostaglandin F2 + NADP(+)

ReviewStatus

5/5

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PGD2 is reduced to 11-epi-PGF2a by AKRIC3

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Aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS is the enzyme involved in NADPH-dependent prostaglandin D2 11-keto reductase activity of reducing prostaglandin D2 (PGD2) to 11-epi-Prostaglandin F2alpha (11-epi-PGF2a) (Liston & Roberts 1985, Koda et al. 2004, Byrns et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
15047184	Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS Niwa, H, Tsutsui, Y, Woodward, DF, Watanabe, K, Ito, S, Koda, N	Arch Biochem Biophys	2004
3862115	Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans Liston, TE, Roberts LJ, 2nd	Proc Natl Acad Sci U S A	1985
20036328	Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer Duan, L, Penning, TM, Blair, IA, Lee, SH, Byrns, MC	J Steroid Biochem Mol Biol	2010