Reactome | PGD2 is reduced to 11-epi-PGF2a by AKRIC3

PGD2 is reduced to 11-epi-PGF2a by AKRIC3

Stable Identifier

R-HSA-2161614

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

H(+) + NADPH + prostaglandin D2 => 11beta-prostaglandin F2 + NADP(+)

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PGD2 is reduced to 11-epi-PGF2a by AKRIC3

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS is the enzyme involved in NADPH-dependent prostaglandin D2 11-keto reductase activity of reducing prostaglandin D2 (PGD2) to 11-epi-Prostaglandin F2alpha (11-epi-PGF2a) (Liston & Roberts 1985, Koda et al. 2004, Byrns et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
15047184	Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS Koda, N, Tsutsui, Y, Niwa, H, Ito, S, Woodward, DF, Watanabe, K	Arch Biochem Biophys	2004
3862115	Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans Liston, TE, Roberts LJ, 2nd	Proc Natl Acad Sci U S A	1985
20036328	Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer Byrns, MC, Duan, L, Lee, SH, Blair, IA, Penning, TM	J Steroid Biochem Mol Biol	2010