CYP2W1 oxidises INDOL

Stable Identifier
R-HSA-211968
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CYP2W1 is a so-called "ophan P450", a cytochrome P450 enzyme which has no defined function or endogenous/xenobiotic substrates. CYP2W1 has recently been shown to be selectively expressed in some forms of cancers and, with the low expression in normal tissues, could be rendered as a possible drug target during cancer therapy (Yoshioka et al. 2006). CYP2W1 can bioactivate several procarcinogens but at lower levels than other P450s. CYP2W1 also shows monooxygenase activity towards the pigment indole (INDOL), an ingredient of perfumes and coal tar.

Literature References
PubMed ID Title Journal Year
16677611 Enzymatic properties of human CYP2W1 expressed in Escherichia coli

Yoshioka, H, Kasai, N, Ikushiro, S, Shinkyo, R, Kamakura, M, Ohta, M, Inouye, K, Sakaki, T

Biochem Biophys Res Commun 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2W1 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created