CYP2W1 oxidises INDOL

Stable Identifier
R-HSA-211968
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
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CYP2W1 oxidises INDOL
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CYP2W1 is a so-called "ophan P450", a cytochrome P450 enzyme which has no defined function or endogenous/xenobiotic substrates. CYP2W1 has recently been shown to be selectively expressed in some forms of cancers and, with the low expression in normal tissues, could be rendered as a possible drug target during cancer therapy (Yoshioka et al. 2006). CYP2W1 can bioactivate several procarcinogens but at lower levels than other P450s. CYP2W1 also shows monooxygenase activity towards the pigment indole (INDOL), an ingredient of perfumes and coal tar.

Literature References
PubMed ID Title Journal Year
16677611 Enzymatic properties of human CYP2W1 expressed in Escherichia coli

Yoshioka, H, Kasai, N, Ikushiro, S, Shinkyo, R, Kamakura, M, Ohta, M, Inouye, K, Sakaki, T

Biochem Biophys Res Commun 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2W1 based) [endoplasmic reticulum membrane]
Physical Entity
Cytochrome P450 (CYP2W1 based) [endoplasmic reticulum membrane]
Activity
monooxygenase activity (0004497)
Orthologous Events
CYP2W1 oxidises INDOL (Bos taurus)
CYP2W1 oxidises INDOL (Canis familiaris)
CYP2W1 oxidises INDOL (Danio rerio)
CYP2W1 oxidises INDOL (Dictyostelium discoideum)
CYP2W1 oxidises INDOL (Gallus gallus)
CYP2W1 oxidises INDOL (Mus musculus)
CYP2W1 oxidises INDOL (Rattus norvegicus)
CYP2W1 oxidises INDOL (Sus scrofa)
CYP2W1 oxidises INDOL (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)