Miscellaneous substrates

Stable Identifier
R-HSA-211958
Type
Pathway
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Miscellaneous substrates
Click the image above or here to open this pathway in the Pathway Browser

Approximately a quarter of the 57 human CYPs still remain "orphans" in the sense that their function, expression sites, and regulation are largely not elucidated. While there is enough experimental evidence to know that all these proteins get made and can catalyze CYP-like reactions in vitro, evidence of in vivo function and substrate specificity is insufficient to allow them to be placed in any of the classes in the functional scheme.

Literature References
PubMed ID Title Journal Year
16126164 Function of human cytochrome P450s: characterization of the orphans

Guengerich, FP, Wu, ZL, Bartleson, CJ

Biochem Biophys Res Commun 2005
15102545 57 varieties: the human cytochromes P450

Lewis, DF

Pharmacogenomics 2004
17786643 Characterization of orphan human cytochromes P450

Stark, K, Guengerich, FP

Drug Metab Rev 2007
Participants
Events
Participant Of
hasEvent
Orthologous Events
Miscellaneous substrates (Bos taurus)
Miscellaneous substrates (Canis familiaris)
Miscellaneous substrates (Danio rerio)
Miscellaneous substrates (Dictyostelium discoideum)
Miscellaneous substrates (Gallus gallus)
Miscellaneous substrates (Mus musculus)
Miscellaneous substrates (Rattus norvegicus)
Miscellaneous substrates (Sus scrofa)
Miscellaneous substrates (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)