Reactome | Miscellaneous substrates

Miscellaneous substrates

Stable Identifier

R-HSA-211958

Type

Pathway

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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Approximately a quarter of the 57 human CYPs still remain "orphans" in the sense that their function, expression sites, and regulation are largely not elucidated. While there is enough experimental evidence to know that all these proteins get made and can catalyze CYP-like reactions in vitro, evidence of in vivo function and substrate specificity is insufficient to allow them to be placed in any of the classes in the functional scheme.

Literature References

PubMed ID	Title	Journal	Year
15102545	57 varieties: the human cytochromes P450 Lewis, DF	Pharmacogenomics	2004
16126164	Function of human cytochrome P450s: characterization of the orphans Wu, ZL, Guengerich, FP, Bartleson, CJ	Biochem Biophys Res Commun	2005
17786643	Characterization of orphan human cytochromes P450 Guengerich, FP, Stark, K	Drug Metab Rev	2007