Reactome | CYP2U1 19-hydroxylates ARA

CYP2U1 19-hydroxylates ARA

Stable Identifier

R-HSA-211960

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

ReviewStatus

5/5

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A novel cytochrome P450, CYP2U1, may play an important role in modulating the arachidonic acid (ARA) signaling pathway. It was discovered by searching the human EST database for homology to existing CYPs and subsequent cloning and expression to obtain the enzyme. CYP2U1 was found to be highly expressed in the thymus and the brain (cerebellum) and found to metabolise ARA to 19-hydroxy-ARA (19HETE) and 20-hydroxy-ARA (20HETE). It is thought that CYP2U1 plays an important physiological role in fatty acid signaling processes in both the cerebellum and thymus (Chuang et al. 1994). The omega-hydroxylation (19) example is described here.

Literature References

PubMed ID	Title	Journal	Year
14660610	CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids Chuang, SS, Helvig, C, Taimi, M, Ramshaw, HA, Collop, AH, Amad, M, White, JA, Petkovich, M, Jones, G, Korczak, B	J Biol Chem	2004