CYP3A43 6b-hydroxylates TEST

Stable Identifier
R-HSA-211959
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CYP3A43 belongs to the cytochrome P450 3A family, of which CYP3A4 is the most active member in the biotransformation of xenobiotics. Testosterone (TEST) metabolites are a major determinant of prostate growth and differentiation. CYP3A43, which is expressed in the prostate, exhibits minor 6-beta-hydroxylation activity towards TEST suggesting CYP3A43 may be involved in the etiology of prostate cancer (Domanski et al. 2001, Zeigler-Johnson et al. 2004).

Literature References
PubMed ID Title Journal Year
11160876 cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450

Domanski, TL, Finta, C, Halpert, JR, Zaphiropoulos, PG

Mol Pharmacol 2001
15548719 CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer

Zeigler-Johnson, C, Friebel, T, Walker, AH, Wang, Y, Spangler, E, Panossian, S, Patacsil, M, Aplenc, R, Wein, AJ, Malkowicz, SB, Rebbeck, TR

Cancer Res 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP3A43 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
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Created