Reactome | CYP3A43 6b-hydroxylates TEST

CYP3A43 6b-hydroxylates TEST

Stable Identifier

R-HSA-211959

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

ReviewStatus

5/5

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CYP3A43 belongs to the cytochrome P450 3A family, of which CYP3A4 is the most active member in the biotransformation of xenobiotics. Testosterone (TEST) metabolites are a major determinant of prostate growth and differentiation. CYP3A43, which is expressed in the prostate, exhibits minor 6-beta-hydroxylation activity towards TEST suggesting CYP3A43 may be involved in the etiology of prostate cancer (Domanski et al. 2001, Zeigler-Johnson et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15548719	CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer Walker, AH, Aplenc, R, Wang, Y, Zeigler-Johnson, C, Panossian, S, Malkowicz, SB, Rebbeck, TR, Friebel, T, Patacsil, M, Spangler, E, Wein, AJ	Cancer Res	2004
11160876	cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450 Domanski, TL, Finta, C, Zaphiropoulos, PG, Halpert, JR	Mol Pharmacol	2001