Reactome | CYP3A43 6b-hydroxylates TEST

CYP3A43 6b-hydroxylates TEST

Stable Identifier

R-HSA-211959

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

ReviewStatus

5/5

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CYP3A43 belongs to the cytochrome P450 3A family, of which CYP3A4 is the most active member in the biotransformation of xenobiotics. Testosterone (TEST) metabolites are a major determinant of prostate growth and differentiation. CYP3A43, which is expressed in the prostate, exhibits minor 6-beta-hydroxylation activity towards TEST suggesting CYP3A43 may be involved in the etiology of prostate cancer (Domanski et al. 2001, Zeigler-Johnson et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15548719	CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer Zeigler-Johnson, C, Friebel, T, Walker, AH, Wang, Y, Spangler, E, Panossian, S, Patacsil, M, Aplenc, R, Wein, AJ, Malkowicz, SB, Rebbeck, TR	Cancer Res	2004
11160876	cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450 Domanski, TL, Finta, C, Halpert, JR, Zaphiropoulos, PG	Mol Pharmacol	2001