CYP3A43 belongs to the cytochrome P450 3A family, of which CYP3A4 is the most active member in the biotransformation of xenobiotics. Testosterone (TEST) metabolites are a major determinant of prostate growth and differentiation. CYP3A43, which is expressed in the prostate, exhibits minor 6-beta-hydroxylation activity towards TEST suggesting CYP3A43 may be involved in the etiology of prostate cancer (Domanski et al. 2001, Zeigler-Johnson et al. 2004).
Walker, AH, Aplenc, R, Wang, Y, Zeigler-Johnson, C, Panossian, S, Malkowicz, SB, Rebbeck, TR, Friebel, T, Patacsil, M, Spangler, E, Wein, AJ
Domanski, TL, Finta, C, Zaphiropoulos, PG, Halpert, JR
monooxygenase activity of CYP3A43 [endoplasmic reticulum membrane]
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