CYP2S1 4-hydroxylates atRA

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CYP2S1 is a recently discovered cytochrome P450 enzyme on the basis of homology searches of databases and was found to be homologous to the CYP2 family of enzymes that are known to metabolize xenobiotics (Rylander et al. 2001). CYP2S1 is expressed in skin cells and is inducible by UV radiation, coal tar and all-trans-retinoic acid (atRA), the latter also serving as a substrate for the enzyme. Expression of CYP2S1 was significantly higher in psoriatic plaque than in normal skin. Psoriasis is a chronic hyperproliferative and inflammatory disorder.

Literature References
PubMed ID Title Journal Year
12711469 Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases

Ibbotson, SH, Ferguson, J, Wolf, CR, Comrie, MM, Evans, AT, Dawe, RS, Deeni, YY, Smith, G

Lancet 2003
Catalyst Activity

retinoic acid 4-hydroxylase activity of CYP2S1 [endoplasmic reticulum membrane]

Orthologous Events
Cite Us!