Reactome | CYP2S1 4-hydroxylates atRA

CYP2S1 4-hydroxylates atRA

Stable Identifier

R-HSA-211874

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

ReviewStatus

5/5

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CYP2S1 is a recently discovered cytochrome P450 enzyme on the basis of homology searches of databases and was found to be homologous to the CYP2 family of enzymes that are known to metabolize xenobiotics (Rylander et al. 2001). CYP2S1 is expressed in skin cells and is inducible by UV radiation, coal tar and all-trans-retinoic acid (atRA), the latter also serving as a substrate for the enzyme. Expression of CYP2S1 was significantly higher in psoriatic plaque than in normal skin. Psoriasis is a chronic hyperproliferative and inflammatory disorder.

Literature References

PubMed ID	Title	Journal	Year
12711469	Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases Smith, G, Wolf, CR, Deeni, YY, Dawe, RS, Evans, AT, Comrie, MM, Ferguson, J, Ibbotson, SH	Lancet	2003