CYP2S1 4-hydroxylates atRA

Stable Identifier
R-HSA-211874
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
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CYP2S1 4-hydroxylates atRA
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CYP2S1 is a recently discovered cytochrome P450 enzyme on the basis of homology searches of databases and was found to be homologous to the CYP2 family of enzymes that are known to metabolize xenobiotics (Rylander et al. 2001). CYP2S1 is expressed in skin cells and is inducible by UV radiation, coal tar and all-trans-retinoic acid (atRA), the latter also serving as a substrate for the enzyme. Expression of CYP2S1 was significantly higher in psoriatic plaque than in normal skin. Psoriasis is a chronic hyperproliferative and inflammatory disorder.

Literature References
PubMed ID Title Journal Year
12711469 Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases

Smith, G, Wolf, CR, Deeni, YY, Dawe, RS, Evans, AT, Comrie, MM, Ferguson, J, Ibbotson, SH

Lancet 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
retinoic acid 4-hydroxylase activity of CYP2S1 [endoplasmic reticulum membrane]
Physical Entity
CYP2S1 [endoplasmic reticulum membrane]
Activity
retinoic acid 4-hydroxylase activity (0008401)
Orthologous Events
CYP2S1 4-hydroxylates atRA (Bos taurus)
CYP2S1 4-hydroxylates atRA (Canis familiaris)
CYP2S1 4-hydroxylates atRA (Danio rerio)
CYP2S1 4-hydroxylates atRA (Dictyostelium discoideum)
CYP2S1 4-hydroxylates atRA (Mus musculus)
CYP2S1 4-hydroxylates atRA (Rattus norvegicus)
CYP2S1 4-hydroxylates atRA (Sus scrofa)
CYP2S1 4-hydroxylates atRA (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)