Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NKX2-2 [nucleoplasm]
Stable Identifier
R-HSA-186537
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NKX2.2
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Regulation of beta-cell development (Homo sapiens)
Regulation of gene expression in beta cells (Homo sapiens)
MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein (Homo sapiens)
NKX2-2 [nucleoplasm] (Homo sapiens)
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells (Homo sapiens)
NEUROG3-dependent synthesis of NKX2-2 (Homo sapiens)
NKX2-2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95096 NKX2-2
Gene Names
NKX2-2, NKX2.2, NKX2B
Chain
chain:1-273
Reference Genes
BioGPS Gene:4821 NKX2-2
COSMIC (genes):NKX2-2 NKX2-2
CTD Gene:4821 NKX2-2
dbSNP Gene:4821 NKX2-2
ENSEMBL:ENSG00000125820 NKX2-2
HGNC:7835 NKX2-2
Monarch:4821 NKX2-2
NCBI Gene:4821 NKX2-2
OMIM:604612 NKX2-2
UCSC:O95096 NKX2-2
Reference Transcript
RefSeq:NM_002509.3 NKX2-2
Other Identifiers
11731863_at
11731864_at
16917774
206915_PM_at
206915_at
33605_at
33606_g_at
3900553
3900554
3900555
3900556
3900557
3900558
3900559
3900561
4821
8065334
A_23_P17522
GE60469
GO:0000785
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0003309
GO:0003323
GO:0003326
GO:0003327
GO:0003329
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0006355
GO:0006357
GO:0007224
GO:0007399
GO:0007420
GO:0009749
GO:0010628
GO:0014003
GO:0014070
GO:0021522
GO:0021529
GO:0021530
GO:0021554
GO:0030154
GO:0030182
GO:0030858
GO:0031018
GO:0032570
GO:0043226
GO:0043565
GO:0045665
GO:0045666
GO:0045944
GO:0048468
GO:0048565
GO:0048665
GO:0048708
GO:0048709
GO:0048714
GO:0048856
GO:0060580
GO:0061101
GO:0140110
HMNXSV003033142
ILMN_1692280
PH_hs_0017216
TC20000692.hg
g4505400_3p_at
Participates
as an output of
NEUROG3-dependent synthesis of NKX2-2 (Homo sapiens)
This entity regulates
Positively
MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein
(Homo sapiens)
Cross References
ENSEMBL
ENST00000377142
,
ENSP00000366347
OpenTargets
ENSG00000125820
HPA
ENSG00000125820-NKX2-2
PRO
O95096
Pharos - Targets
O95096
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text