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HS(6)-GPC4 [plasma membrane]
Stable Identifier
R-HSA-2076677
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GPC4, Glypican-4, GPC4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HS-GAG degradation (Homo sapiens)
HS-GAGs translocate to the lysosome for degradation (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75487 GPC4
Gene Names
GPC4, UNQ474/PRO937
Chain
signal peptide:1-18, chain:19-529, chain:19-, propeptide:530-556
Reference Genes
BioGPS Gene:2239 GPC4
COSMIC (genes):GPC4 GPC4
CTD Gene:2239 GPC4
dbSNP Gene:2239 GPC4
ENSEMBL:ENSG00000076716 GPC4
ENSEMBL_homo_sapiens_GENE:ENSG00000076716 GPC4
HGNC:4452 GPC4
KEGG Gene (Homo sapiens):2239 GPC4
Monarch:2239 GPC4
NCBI Gene:2239 GPC4
OMIM:300168 GPC4
UCSC:O75487 GPC4
Reference Transcript
RefSeq:NM_001448.2 GPC4
Other Identifiers
0004560450
11727403_at
11727404_a_at
17114272
204983_s_at
204984_at
2239
30836
36508_at
4022381
4022382
4022383
4022384
4022385
4022386
4022387
4022389
4022390
4022391
4022392
4022393
4022396
4022405
4022411
4022438
4022439
52756_at
8175217
A_23_P435407
AAC31899
AAC69991
AAH17166
AAL11018
AAQ88871
AF030186
AF064826
AK304207
AK312605
AL034400
AL109623
AY052833
AY358507
BAG35494
BAG65082
BC017166
CCDS14637
CH471107
EAX11772
ENSG00000076716
ENSP00000359864
ENST00000370828
EntrezGene:2239
g3420276_3p_a_at
g4504082_3p_at
GE54232
GO:0001523
GO:0003674
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0005886
GO:0006024
GO:0006027
GO:0006629
GO:0007165
GO:0007267
GO:0008150
GO:0009056
GO:0009058
GO:0009897
GO:0009966
GO:0016020
GO:0022607
GO:0031012
GO:0031225
GO:0043202
GO:0043226
GO:0046658
GO:0048856
GO:0060071
GO:0062023
GO:0070062
GO:0098696
GO:0098978
GO:0099026
GO:1904929
GO:1905606
GPC4
GPC4-201
HGNC:4452
HPA030836
ILMN_1789502
IPR001863
IPR019803
IPR031180
MIM:194070
MIM:300168
MIM:312870
NM_001448
NP_001439
PF01153
PH_hs_0003752
TC0X001376.hg
uc004exc.2
UPI0000001C14
Participant Of
hasMember
HS/HPIN-PGs [plasma membrane]
Other forms of this molecule
GPC4 [plasma membrane]
Heparan-GPC4 [Golgi lumen]
Heparan(1)-GPC4 [Golgi lumen]
Heparan(2)-GPC4 [Golgi lumen]
Heparan(3)-GPC4 [Golgi lumen]
Heparan(4)-GPC4 [Golgi lumen]
Gal-Gal-Xyl-GPC4 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC4 [Golgi lumen]
Gal-Xyl-GPC4 [Golgi lumen]
XylS-GPC4 [Golgi lumen]
GPC4 [Golgi lumen]
HS(6)-GPC4 [lysosomal lumen]
GPC4 [lysosomal lumen]
HS(5)-GPC4 [Golgi lumen]
HS(4)-GPC4 [Golgi lumen]
HS(2)-GPC4 [Golgi lumen]
HS(3)-GPC4 [Golgi lumen]
HS(6)-GPC4 [Golgi lumen]
HS(1)-GPC4 [Golgi lumen]
HS(4)-GPC4 [plasma membrane]
HS(2)-GPC4 [plasma membrane]
HS(1)-GPC4 [plasma membrane]
HS(3)-GPC4 [plasma membrane]
HS(5)-GPC4 [plasma membrane]
Inferred To
Homologues of HS(6)-GPC4 [plasma membrane] (Drosophila melanogaster)
Homologues of HS(6)-GPC4 [plasma membrane] (Gallus gallus)
Homologues of HS(6)-GPC4 [plasma membrane] (Taeniopygia guttata)
HS(6)-GPC4 [plasma membrane] (Bos taurus)
HS(6)-GPC4 [plasma membrane] (Caenorhabditis elegans)
HS(6)-GPC4 [plasma membrane] (Canis familiaris)
HS(6)-GPC4 [plasma membrane] (Danio rerio)
HS(6)-GPC4 [plasma membrane] (Drosophila melanogaster)
HS(6)-GPC4 [plasma membrane] (Gallus gallus)
HS(6)-GPC4 [plasma membrane] (Mus musculus)
HS(6)-GPC4 [plasma membrane] (Rattus norvegicus)
HS(6)-GPC4 [plasma membrane] (Sus scrofa)
HS(6)-GPC4 [plasma membrane] (Taeniopygia guttata)
HS(6)-GPC4 [plasma membrane] (Xenopus tropicalis)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63666) at unknown position
Modification
beta-D-IdoA-(1->4)-alpha-D-GlcNS6S-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_001439.2
OpenTargets
ENSG00000076716
GeneCards
O75487
PRO
O75487
Orphanet
17714
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.488
2
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