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XylS-GPC6 [Golgi lumen]
Stable Identifier
R-HSA-2064057
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
xylosyl-GPC6, Glypican-6 component recommendedName: Secreted glypican-6 /component, GPC6_HUMAN, GPC6
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective B4GALT7 causes EDS, progeroid type (Homo sapiens)
Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-GPC6 [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-GPC6 [Golgi lumen] (Homo sapiens)
XYLTs transfer Xyl to core protein (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-GPC6 [Golgi lumen] (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-GPC6 [Golgi lumen] (Homo sapiens)
XYLTs transfer Xyl to core protein (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-GPC6 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y625 GPC6
Gene Names
GPC6, UNQ369/PRO705
Chain
signal peptide:1-23, chain:24-529, chain:24-, propeptide:530-555
Reference Genes
BioGPS Gene:10082 GPC6
COSMIC (genes):GPC6 GPC6
CTD Gene:10082 GPC6
dbSNP Gene:10082 GPC6
ENSEMBL:ENSG00000183098 GPC6
HGNC:4454 GPC6
KEGG:hsa:10082 GPC6
Monarch:10082 GPC6
NCBI Gene:10082 GPC6
OMIM:604404 GPC6
UCSC:Q9Y625 GPC6
Reference Transcript
RefSeq:NM_005708.4 GPC6
Other Identifiers
10082
11726014_at
11726015_at
11726016_at
16775811
223730_PM_at
223730_at
227059_PM_at
227059_at
3496636
3496638
3496639
3496640
3496694
3496695
3496726
3496754
3496755
3496756
3496792
3496797
3496817
3496822
3496824
3496825
3496826
3496827
3496828
3496829
50307_at
74357_at
7969613
88630_at
A_14_P107388
A_14_P108843
A_14_P126561
A_23_P371682
A_32_P97169
GE58375
GO:0005515
GO:0005576
GO:0005634
GO:0005794
GO:0005796
GO:0005886
GO:0009966
GO:0009986
GO:0015026
GO:0016477
GO:0030312
GO:0031012
GO:0043202
GO:0043226
GO:0045202
GO:0048870
GO:0060089
GO:0062023
GO:0098552
GO:0098696
GO:0098978
HMNXSV003022177
Hs.75113.2.A1_3p_at
ILMN_1805216
ILMN_1912185
PH_hs_0026584
PH_hs_0037802
TC13000329.hg
g4877642_3p_at
Participates
as a member of
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
Other forms of this molecule
HS(4)-GPC6 [plasma membrane]
HS(6)-GPC6 [plasma membrane]
HS(2)-GPC6 [plasma membrane]
HS(1)-GPC6 [plasma membrane]
HS(3)-GPC6 [plasma membrane]
HS(5)-GPC6 [plasma membrane]
Gal-Xyl-GPC6 [Golgi lumen]
GPC6 [Golgi lumen]
Gal-Gal-Xyl-GPC6 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC6 [Golgi lumen]
HS(3)-GPC6 [Golgi lumen]
HS(4)-GPC6 [Golgi lumen]
HS(2)-GPC6 [Golgi lumen]
HS(1)-GPC6 [Golgi lumen]
Heparan(4)-GPC6 [Golgi lumen]
Heparan(3)-GPC6 [Golgi lumen]
Heparan(2)-GPC6 [Golgi lumen]
Heparan(1)-GPC6 [Golgi lumen]
Heparan-GPC6 [Golgi lumen]
HS(5)-GPC6 [Golgi lumen]
HS(6)-GPC6 [Golgi lumen]
HS(6)-GPC6 [lysosomal lumen]
GPC6 [lysosomal lumen]
Inferred To
GPC6 [Golgi lumen]
(Canis familiaris)
GPC6 [Golgi lumen]
(Sus scrofa)
gpc6a [Golgi lumen]
(Danio rerio)
XylS-GPC6 [Golgi lumen]
(Caenorhabditis elegans)
gpc6 [Golgi lumen]
(Xenopus tropicalis)
Gpc6 [Golgi lumen]
(Mus musculus)
Gpc6 [Golgi lumen]
(Rattus norvegicus)
dlp [Golgi lumen]
(Drosophila melanogaster)
lon-2 [Golgi lumen]
(Caenorhabditis elegans)
Homologues of XylS-GPC6 [Golgi lumen]
(Caenorhabditis elegans)
gpn-1 [Golgi lumen]
(Caenorhabditis elegans)
Modified Residues
Name
O-xylosyl-L-serine at unknown position
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_005699.1
ENSEMBL
ENSP00000366246
,
ENST00000377047
OpenTargets
ENSG00000183098
HPA
ENSG00000183098-GPC6
PRO
Q9Y625
Pharos - Targets
Q9Y625
Orphanet
GPC6
GlyGen
Q9Y625
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
3
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