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CSE-NCAN [extracellular region]
Stable Identifier
R-HSA-2064044
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
_NCAN, Neurocan
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
Tenascins C, R, (X, N) bind lecticans (Homo sapiens)
Lecticans [extracellular region] (Homo sapiens)
Neurocan [extracellular region] (Homo sapiens)
CSE-NCAN [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N):Lecticans [extracellular region] (Homo sapiens)
Lecticans [extracellular region] (Homo sapiens)
Neurocan [extracellular region] (Homo sapiens)
CSE-NCAN [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
CS/DS degradation (Homo sapiens)
DSPG and CSPG translocate to the lysosome for degradation (Homo sapiens)
CSPGs [extracellular region] (Homo sapiens)
CSE-PGs [extracellular region] (Homo sapiens)
CSE-NCAN [extracellular region] (Homo sapiens)
Chondroitin sulfate biosynthesis (Homo sapiens)
CSPG is secreted (Homo sapiens)
CSPGs [extracellular region] (Homo sapiens)
CSE-PGs [extracellular region] (Homo sapiens)
CSE-NCAN [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14594 NCAN
Gene Names
NCAN, CSPG3, NEUR
Chain
signal peptide:1-22, chain:23-1321
Reference Genes
BioGPS Gene:1463 NCAN
COSMIC (genes):NCAN NCAN
CTD Gene:1463 NCAN
dbSNP Gene:1463 NCAN
ENSEMBL:ENSG00000130287 NCAN
ENSEMBL_homo_sapiens_GENE:ENSG00000130287.14 NCAN
HGNC:2465 NCAN
KEGG Gene (Homo sapiens):1463 NCAN
Monarch:1463 NCAN
NCBI Gene:1463 NCAN
OMIM:600826 NCAN
UCSC:O14594 NCAN
Reference Transcript
RefSeq:NM_004386.2 NCAN
Other Identifiers
11724892_a_at
11752214_a_at
1463
16859969
205143_PM_at
205143_at
32642_at
3825610
3825611
3825612
3825613
3825614
3825615
3825616
3825620
3825621
3825622
3825623
3825624
3825625
3825626
3825627
3825628
3825631
3825632
3825633
3825637
3825638
3825639
3825642
3825643
3825644
3825645
3825646
3825647
8027152
A_23_P153797
GE54206
GO:0001501
GO:0002052
GO:0005509
GO:0005540
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0007155
GO:0007417
GO:0010001
GO:0030154
GO:0030246
GO:0030312
GO:0031012
GO:0043202
GO:0043226
GO:0045202
GO:0048856
GO:0072534
HMNXSV003034591
ILMN_1683211
PH_hs_0010081
TC19000370.hg
g4758083_3p_at
Participates
as a member of
Neurocan [extracellular region] (Homo sapiens)
CSE-PGs [extracellular region] (Homo sapiens)
Other forms of this molecule
dermatan-NCAN [Golgi lumen]
D2,4(S)2-NCAN [Golgi lumen]
D2,4,4(S)3-NCAN [Golgi lumen]
D4S-NCAN [Golgi lumen]
CSE-NCAN [lysosomal lumen]
C6S-NCAN [lysosomal lumen]
C4S-NCAN [lysosomal lumen]
D2,4(S)2-NCAN [lysosomal lumen]
D4S-NCAN [lysosomal lumen]
D4S-NCAN [extracellular region]
D2,4(S)2-NCAN [extracellular region]
D2,4,4(S)3-NCAN [extracellular region]
NCAN [lysosomal lumen]
D2,4,4(S)3-NCAN [lysosomal lumen]
NCAN [plasma membrane]
Gal-Gal-Xyl-NCAN [Golgi lumen]
GlcA-Gal-Gal-Xyl-NCAN [Golgi lumen]
Gal-Xyl-NCAN [Golgi lumen]
XylS-NCAN [Golgi lumen]
NCAN [Golgi lumen]
chondroitin(1)-NCAN [Golgi lumen]
chondroitin(2)-NCAN [Golgi lumen]
chondroitin(3)-NCAN [Golgi lumen]
C4S-NCAN [Golgi lumen]
C6S-NCAN [Golgi lumen]
CSE-NCAN [Golgi lumen]
C4S-NCAN [extracellular region]
C6S-NCAN [extracellular region]
Inferred To
CSE-NCAN [extracellular region]
(Gallus gallus)
ncan [extracellular region]
(Xenopus tropicalis)
Ncan [extracellular region]
(Mus musculus)
Ncan [extracellular region]
(Rattus norvegicus)
ncanb [extracellular region]
(Danio rerio)
NCAN [extracellular region]
(Bos taurus)
NCAN [extracellular region]
(Canis familiaris)
NCAN [extracellular region]
(Sus scrofa)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63515) at unknown position
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4,6S2-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_004377.2
OpenTargets
ENSG00000130287
HPA
ENSG00000130287-NCAN
GeneCards
O14594
Ensembl
ENSG00000130287
,
ENSP00000252575
,
ENST00000252575
PRO
O14594
Pharos - Targets
O14594
HMDB Protein
HMDBP02407
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