Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
C4S-NCAN [extracellular region]
Stable Identifier
R-HSA-2064043
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
_NCAN, Neurocan
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
Tenascins C, R, (X, N) bind lecticans (Homo sapiens)
Lecticans [extracellular region] (Homo sapiens)
Neurocan [extracellular region] (Homo sapiens)
C4S-NCAN [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N):Lecticans [extracellular region] (Homo sapiens)
Lecticans [extracellular region] (Homo sapiens)
Neurocan [extracellular region] (Homo sapiens)
C4S-NCAN [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
CS/DS degradation (Homo sapiens)
DSPG and CSPG translocate to the lysosome for degradation (Homo sapiens)
CSPGs [extracellular region] (Homo sapiens)
C4S-PGs [extracellular region] (Homo sapiens)
C4S-NCAN [extracellular region] (Homo sapiens)
Chondroitin sulfate biosynthesis (Homo sapiens)
CSPG is secreted (Homo sapiens)
CSPGs [extracellular region] (Homo sapiens)
C4S-PGs [extracellular region] (Homo sapiens)
C4S-NCAN [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14594 NCAN
Gene Names
NCAN, CSPG3, NEUR
Chain
signal peptide:1-22, chain:23-1321
Reference Genes
BioGPS Gene:1463 NCAN
COSMIC (genes):NCAN NCAN
CTD Gene:1463 NCAN
dbSNP Gene:1463 NCAN
ENSEMBL:ENSG00000130287 NCAN
ENSEMBL_homo_sapiens_GENE:ENSG00000130287.14 NCAN
HGNC:2465 NCAN
KEGG Gene (Homo sapiens):1463 NCAN
Monarch:1463 NCAN
NCBI Gene:1463 NCAN
OMIM:600826 NCAN
UCSC:O14594 NCAN
Reference Transcript
RefSeq:NM_004386.2 NCAN
Other Identifiers
11724892_a_at
11752214_a_at
1463
16859969
205143_PM_at
205143_at
32642_at
3825610
3825611
3825612
3825613
3825614
3825615
3825616
3825620
3825621
3825622
3825623
3825624
3825625
3825626
3825627
3825628
3825631
3825632
3825633
3825637
3825638
3825639
3825642
3825643
3825644
3825645
3825646
3825647
8027152
A_23_P153797
GE54206
GO:0001501
GO:0002052
GO:0005509
GO:0005540
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0007155
GO:0007417
GO:0010001
GO:0030154
GO:0030246
GO:0030312
GO:0031012
GO:0043202
GO:0043226
GO:0045202
GO:0048856
GO:0072534
HMNXSV003034591
ILMN_1683211
PH_hs_0010081
TC19000370.hg
g4758083_3p_at
Participates
as a member of
Neurocan [extracellular region] (Homo sapiens)
C4S-PGs [extracellular region] (Homo sapiens)
Other forms of this molecule
dermatan-NCAN [Golgi lumen]
D2,4(S)2-NCAN [Golgi lumen]
D2,4,4(S)3-NCAN [Golgi lumen]
D4S-NCAN [Golgi lumen]
CSE-NCAN [lysosomal lumen]
C6S-NCAN [lysosomal lumen]
C4S-NCAN [lysosomal lumen]
D2,4(S)2-NCAN [lysosomal lumen]
D4S-NCAN [lysosomal lumen]
D4S-NCAN [extracellular region]
D2,4(S)2-NCAN [extracellular region]
D2,4,4(S)3-NCAN [extracellular region]
NCAN [lysosomal lumen]
D2,4,4(S)3-NCAN [lysosomal lumen]
CSE-NCAN [extracellular region]
NCAN [plasma membrane]
Gal-Gal-Xyl-NCAN [Golgi lumen]
GlcA-Gal-Gal-Xyl-NCAN [Golgi lumen]
Gal-Xyl-NCAN [Golgi lumen]
XylS-NCAN [Golgi lumen]
NCAN [Golgi lumen]
chondroitin(1)-NCAN [Golgi lumen]
chondroitin(2)-NCAN [Golgi lumen]
chondroitin(3)-NCAN [Golgi lumen]
C4S-NCAN [Golgi lumen]
C6S-NCAN [Golgi lumen]
CSE-NCAN [Golgi lumen]
C6S-NCAN [extracellular region]
Inferred To
C4S-NCAN [extracellular region]
(Gallus gallus)
ncan [extracellular region]
(Xenopus tropicalis)
Ncan [extracellular region]
(Mus musculus)
Ncan [extracellular region]
(Rattus norvegicus)
ncanb [extracellular region]
(Danio rerio)
NCAN [extracellular region]
(Bos taurus)
NCAN [extracellular region]
(Canis familiaris)
NCAN [extracellular region]
(Sus scrofa)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63513) at unknown position
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_004377.2
OpenTargets
ENSG00000130287
HPA
ENSG00000130287-NCAN
GeneCards
O14594
Ensembl
ENSG00000130287
,
ENSP00000252575
,
ENST00000252575
PRO
O14594
Pharos - Targets
O14594
HMDB Protein
HMDBP02407
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text