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D2,4,4(S)3-NCAN [lysosomal lumen]
Stable Identifier
R-HSA-2065111
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
_NCAN, Neurocan
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
CS/DS degradation (Homo sapiens)
DS is cleaved from its proteoglycan (Homo sapiens)
D2,4,4(S)3-PGs [lysosomal lumen] (Homo sapiens)
D2,4,4(S)3-NCAN [lysosomal lumen] (Homo sapiens)
DSPG and CSPG translocate to the lysosome for degradation (Homo sapiens)
DSPGs [lysosomal lumen] (Homo sapiens)
D2,4,4(S)3-PGs [lysosomal lumen] (Homo sapiens)
D2,4,4(S)3-NCAN [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14594 NCAN
Gene Names
NCAN, CSPG3, NEUR
Chain
signal peptide:1-22, chain:23-1321
Reference Genes
BioGPS Gene:1463 NCAN
COSMIC (genes):NCAN NCAN
CTD Gene:1463 NCAN
dbSNP Gene:1463 NCAN
ENSEMBL:ENSG00000130287 NCAN
HGNC:2465 NCAN
KEGG:hsa:1463 NCAN
Monarch:1463 NCAN
NCBI Gene:1463 NCAN
OMIM:600826 NCAN
UCSC:O14594 NCAN
Reference Transcript
RefSeq:NM_004386.2 NCAN
Other Identifiers
11724892_a_at
11752214_a_at
1463
16859969
205143_PM_at
205143_at
32642_at
3825610
3825611
3825612
3825613
3825614
3825615
3825616
3825620
3825621
3825622
3825623
3825624
3825625
3825626
3825627
3825628
3825631
3825632
3825633
3825634
3825635
3825637
3825638
3825639
3825640
3825641
3825642
3825643
3825644
3825645
3825646
3825647
42903_at
8027152
86518_at
A_23_P153797
GE54206
GO:0001501
GO:0002052
GO:0005509
GO:0005540
GO:0005576
GO:0005615
GO:0005796
GO:0007155
GO:0007417
GO:0010001
GO:0012505
GO:0030154
GO:0030246
GO:0030312
GO:0031012
GO:0043202
GO:0045202
GO:0048856
GO:0072534
HMNXSV003034591
ILMN_1683211
PH_hs_0010081
TC19000370.hg
g4758083_3p_at
Participates
as a member of
D2,4,4(S)3-PGs [lysosomal lumen] (Homo sapiens)
Other forms of this molecule
NCAN [plasma membrane]
XylS-NCAN [Golgi lumen]
Gal-Xyl-NCAN [Golgi lumen]
NCAN [Golgi lumen]
Gal-Gal-Xyl-NCAN [Golgi lumen]
GlcA-Gal-Gal-Xyl-NCAN [Golgi lumen]
D2,4(S)2-NCAN [Golgi lumen]
dermatan-NCAN [Golgi lumen]
D4S-NCAN [Golgi lumen]
D2,4,4(S)3-NCAN [Golgi lumen]
chondroitin(3)-NCAN [Golgi lumen]
C4S-NCAN [Golgi lumen]
chondroitin(2)-NCAN [Golgi lumen]
chondroitin(1)-NCAN [Golgi lumen]
D2,4,4(S)3-NCAN [extracellular region]
D2,4(S)2-NCAN [extracellular region]
D4S-NCAN [extracellular region]
C6S-NCAN [Golgi lumen]
CSE-NCAN [Golgi lumen]
C4S-NCAN [extracellular region]
C6S-NCAN [extracellular region]
CSE-NCAN [extracellular region]
C4S-NCAN [lysosomal lumen]
C6S-NCAN [lysosomal lumen]
CSE-NCAN [lysosomal lumen]
NCAN [lysosomal lumen]
D4S-NCAN [lysosomal lumen]
D2,4(S)2-NCAN [lysosomal lumen]
Inferred To
Ncan [lysosomal lumen]
(Mus musculus)
Ncan [lysosomal lumen]
(Rattus norvegicus)
ncanb [lysosomal lumen]
(Danio rerio)
ncan [lysosomal lumen]
(Xenopus tropicalis)
NCAN [lysosomal lumen]
(Bos taurus)
NCAN [lysosomal lumen]
(Canis familiaris)
NCAN [lysosomal lumen]
(Sus scrofa)
D2,4,4(S)3-NCAN [lysosomal lumen]
(Gallus gallus)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63519) at unknown position
Modification
beta-D-GalNAc4S-(1->4)-beta-D-IdoA2S-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_004377.2
OpenTargets
ENSG00000130287
ENSEMBL
ENSP00000252575
,
ENST00000252575
HPA
ENSG00000130287-NCAN
PRO
O14594
Pharos - Targets
O14594
GlyGen
O14594
HMDB Protein
HMDBP02407
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