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ANGPT1 [extracellular region]
Stable Identifier
R-HSA-204854
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Angiopoietin-1
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Tie2 Signaling (Homo sapiens)
Dimerization of Tie2/Ang1 complex (Homo sapiens)
2xANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of SOS-1 to Tie2 bound Grb2 (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Dok-2 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Tie2 and Dok-2 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Grb14 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Tie2 and Grb14 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Grb2 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Grb7 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Tie2:Grb7 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Shc1 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Shp2 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
pTie2 and SHP2 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and p85 of PI3K (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
p85 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 with Ang1 (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Trans-phosphorylation of Tie2 (Homo sapiens)
2xANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Phosphorylated Tie2 in Tie2/Akt dimer [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15389 ANGPT1
Gene Names
ANGPT1, KIAA0003
Chain
signal peptide:1-15, chain:16-498
Reference Genes
BioGPS Gene:284 ANGPT1
COSMIC (genes):ANGPT1 ANGPT1
CTD Gene:284 ANGPT1
dbSNP Gene:284 ANGPT1
ENSEMBL:ENSG00000154188.10 ANGPT1
HGNC:484 ANGPT1
KEGG Gene (Homo sapiens):284 ANGPT1
Monarch:284 ANGPT1
NCBI Gene:284 ANGPT1
OMIM:601667 ANGPT1
UCSC:Q15389 ANGPT1
Reference Transcript
RefSeq:NM_001314051.1 ANGPT1
RefSeq:NM_001146.4 ANGPT1
RefSeq:NM_001199859.2 ANGPT1
Other Identifiers
11726691_a_at
11726692_at
11726693_s_at
17080082
1929_at
205608_PM_s_at
205608_s_at
205609_PM_at
205609_at
284
3148464
3148465
3148466
3148468
3148473
3148475
3148478
3148479
3148480
3148481
3148486
3148488
3148510
3148511
3148512
3148513
39315_at
8152297
A_23_P216023
A_24_P60887
D13628_at
GE57062
GO:0001525
GO:0001701
GO:0001933
GO:0001934
GO:0002040
GO:0002092
GO:0002376
GO:0002719
GO:0003013
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005902
GO:0006790
GO:0006886
GO:0006913
GO:0007155
GO:0007162
GO:0007169
GO:0007171
GO:0010595
GO:0010628
GO:0012501
GO:0014068
GO:0014842
GO:0016192
GO:0023052
GO:0030097
GO:0030154
GO:0030210
GO:0030312
GO:0030971
GO:0031012
GO:0031398
GO:0031589
GO:0032680
GO:0033138
GO:0034394
GO:0036211
GO:0042308
GO:0042802
GO:0043066
GO:0043116
GO:0043122
GO:0043226
GO:0043393
GO:0043524
GO:0043536
GO:0045121
GO:0045785
GO:0048014
GO:0048856
GO:0048870
GO:0050731
GO:0050918
GO:0051402
GO:0051897
GO:0062023
GO:0065003
GO:0070062
GO:0070374
GO:0072012
GO:1901135
GO:1905605
GO:2000352
GO:2000446
HMNXSV003015553
ILMN_1677723
ILMN_2086890
PH_hs_0000329
TC08001521.hg
g1907326_3p_a_at
g4502086_3p_at
Participates
as an input of
Interaction of Tie2 with Ang1 (Homo sapiens)
as a component of
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
Inferred To
Ghost homologue of ANGPT1 [extracellular region]
(Caenorhabditis elegans)
Angpt1 [extracellular region]
(Mus musculus)
Angpt1 [extracellular region]
(Rattus norvegicus)
angpt1 [extracellular region]
(Xenopus tropicalis)
AAF57948 [extracellular region]
(Drosophila melanogaster)
ANGPT1 [extracellular region]
(Bos taurus)
ANGPT1 [extracellular region]
(Canis familiaris)
ANGPT1 [extracellular region]
(Danio rerio)
ANGPT1 [extracellular region]
(Gallus gallus)
ANGPT1 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001186788.1
,
NP_001300980.1
,
NP_001137.2
OpenTargets
ENSG00000154188
GeneCards
Q15389
HPA
ENSG00000154188-ANGPT1
Ensembl
ENSP00000297450
,
ENSP00000428340
,
ENSG00000154188
,
ENST00000517746
,
ENST00000297450
PRO
Q15389
Pharos - Targets
Q15389
Orphanet
28060
PDB
4K0V
,
4EPU
,
4JYO
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q02763 TEK
2
TEK [plasma membrane]
(R-HSA-197755)
p-5Y,S1119-TEK [plasma membrane]
(R-HSA-204772)
0.609
2
UniProt:Q15389 ANGPT1
1
ANGPT1 [extracellular region]
(R-HSA-204854)
0.524
3
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