Reactome | ANGPT1 [extracellular region]

ANGPT1 [extracellular region]

Stable Identifier

R-HSA-204854

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Angiopoietin-1

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
        
        Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
        
        ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
        
        ANGPT1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15389 ANGPT1

Gene Names

ANGPT1, KIAA0003

Chain

signal peptide:1-15, chain:16-498

Reference Genes

BioGPS Gene:284 ANGPT1

COSMIC (genes):ANGPT1 ANGPT1

CTD Gene:284 ANGPT1

dbSNP Gene:284 ANGPT1

ENSEMBL:ENSG00000154188 ANGPT1

HGNC:484 ANGPT1

KEGG Gene (Homo sapiens):284 ANGPT1

Monarch:284 ANGPT1

NCBI Gene:284 ANGPT1

OMIM:601667 ANGPT1

UCSC:Q15389 ANGPT1

Reference Transcript

Other Identifiers

0000110053

0004060309

11726691_a_at

11726692_at

11726693_s_at

17080082

1929_at

205608_s_at

205609_at

284

3148464

3148465

3148466

3148468

3148473

3148475

3148478

3148479

3148480

3148481

3148486

3148488

3148510

3148511

3148512

3148513

39315_at

8152297

A_23_P216023

A_24_P60887

D13628_at

GE57062

GO:0000165

GO:0001525

GO:0001701

GO:0001933

GO:0001934

GO:0002040

GO:0002092

GO:0002376

GO:0002719

GO:0003013

GO:0003674

GO:0005102

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005886

GO:0005902

GO:0006464

GO:0006790

GO:0006810

GO:0006913

GO:0007155

GO:0007162

GO:0007165

GO:0007169

GO:0007171

GO:0007275

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0009790

GO:0010595

GO:0010628

GO:0014068

GO:0014842

GO:0015031

GO:0016192

GO:0019899

GO:0022607

GO:0030097

GO:0030154

GO:0030210

GO:0030971

GO:0031012

GO:0031398

GO:0031589

GO:0032680

GO:0033138

GO:0034394

GO:0040011

GO:0042308

GO:0042592

GO:0043066

GO:0043116

GO:0043122

GO:0043226

GO:0043393

GO:0043524

GO:0043536

GO:0044281

GO:0045121

GO:0045785

GO:0048014

GO:0048646

GO:0048856

GO:0048870

GO:0050731

GO:0050900

GO:0050918

GO:0051897

GO:0062023

GO:0065003

GO:0070062

GO:0070374

GO:0072012

GO:1905605

GO:2000352

GO:2000446

HMNXSV003015553

ILMN_1677723

ILMN_1688100

ILMN_2086890

PH_hs_0000329

TC08001521.hg

g1907326_3p_a_at

g4502086_3p_at

Participates

as an input of

Interaction of Tie2 with Ang1 (Homo sapiens)

as a component of

Inferred To

FBpp0074674 [extracellular region] (Drosophila melanogaster)

Angpt1 [extracellular region] (Mus musculus)

Angpt1 [extracellular region] (Rattus norvegicus)

angpt1 [extracellular region] (Danio rerio)

angpt1 [extracellular region] (Xenopus tropicalis)

CG6676 [extracellular region] (Drosophila melanogaster)

sca [extracellular region] (Drosophila melanogaster)

Homologues of ANGPT1 [extracellular region] (Caenorhabditis elegans)

Homologues of ANGPT1 [extracellular region] (Drosophila melanogaster)

ANGPT1 [extracellular region] (Caenorhabditis elegans)

ANGPT1 [extracellular region] (Canis familiaris)

ANGPT1 [extracellular region] (Gallus gallus)

ANGPT1 [extracellular region] (Sus scrofa)

FBpp0082632 [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_001300980.1, NP_001186788.1, NP_001137.2

OpenTargets

ENSG00000154188

HPA

ENSG00000154188-ANGPT1

GeneCards

Q15389

Ensembl

ENSP00000297450, ENST00000297450, ENSP00000428340, ENST00000517746, ENSG00000154188

PRO

Q15389

Pharos - Targets

Q15389

Orphanet

28060

GlyGen

Q15389

PDB

4JYO, 4K0V, 4EPU

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02763 TEK	2	TEK [plasma membrane] (R-HSA-197755) p-5Y,S1119-TEK [plasma membrane] (R-HSA-204772)	0.609	2
UniProt:Q15389 ANGPT1	1	ANGPT1 [extracellular region] (R-HSA-204854)	0.524	3