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ANGPT1
Stable Identifier
R-HSA-204854
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Angiopoietin-1
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Tie2 Signaling (Homo sapiens)
Dimerization of Tie2/Ang1 complex (Homo sapiens)
2xANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of SOS-1 to Tie2 bound Grb2 (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Dok-2 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Tie2 and Dok-2 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Grb14 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Tie2 and Grb14 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Grb2 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Grb7 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Tie2:Grb7 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Shc1 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and Shp2 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
pTie2 and SHP2 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 and p85 of PI3K (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
p85 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Interaction of Tie2 with Ang1 (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Trans-phosphorylation of Tie2 (Homo sapiens)
2xANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Phosphorylated Tie2 in Tie2/Akt dimer [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
ANGPT1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15389 ANGPT1
Gene Names
ANGPT1, KIAA0003
Chain
signal peptide:1-15, chain:16-498
Reference Genes
BioGPS Gene:284 ANGPT1
COSMIC (genes):ANGPT1 ANGPT1
CTD Gene:284 ANGPT1
dbSNP Gene:284 ANGPT1
ENSEMBL:ENSG00000154188 ANGPT1
HGNC:484 ANGPT1
KEGG Gene (Homo sapiens):hsa:284 ANGPT1
Monarch:284 ANGPT1
NCBI Gene:284 ANGPT1
OMIM:601667 ANGPT1
UCSC:Q15389 ANGPT1
Reference Transcript
RefSeq:NM_001199859.2 ANGPT1
RefSeq:NM_001314051.1 ANGPT1
RefSeq:NM_001146.4 ANGPT1
Other Identifiers
0000110053
0004060309
11726691_a_at
11726692_at
11726693_s_at
17080082
17815
18793
18816
1929_at
205608_s_at
205609_at
284
3148464
3148465
3148466
3148468
3148473
3148475
3148478
3148479
3148480
3148481
3148486
3148488
3148510
3148511
3148512
3148513
39315_at
4EPU
4JYO
4K0V
8152297
A_23_P216023
A_24_P60887
ANGPT1
ANGPT1-201
ANGPT1-202
B4DTQ9
CAB017815
CCDS56551
CCDS6306
D13628_at
ENSG00000154188
ENSP00000297450
ENSP00000428340
ENST00000297450
ENST00000517746
EntrezGene:284
g1907326_3p_a_at
g4502086_3p_at
GE57062
GO:0000165
GO:0001525
GO:0001701
GO:0001933
GO:0002040
GO:0002092
GO:0002740
GO:0005088
GO:0005102
GO:0005576
GO:0005615
GO:0005622
GO:0005886
GO:0005902
GO:0007162
GO:0007169
GO:0007171
GO:0007275
GO:0010595
GO:0014068
GO:0014842
GO:0030097
GO:0030154
GO:0030210
GO:0030971
GO:0031398
GO:0031589
GO:0032680
GO:0033138
GO:0034394
GO:0042308
GO:0043066
GO:0043116
GO:0043122
GO:0043393
GO:0043524
GO:0043536
GO:0043547
GO:0045121
GO:0045785
GO:0048014
GO:0050731
GO:0050900
GO:0050918
GO:0051897
GO:0070062
GO:0070374
GO:0072012
GO:2000352
GO:2000446
HGNC:484
HPA018793
HPA018816
Hs.369675
ILMN_1677723
ILMN_1688100
ILMN_2086890
MIM:601667
NM_001146
NM_001199859
NP_001137
NP_001186788
PF00147
PH_hs_0000329
SM00186
TC08001521.hg
uc003ymn.4
uc003ymo.4
UPI0000034766
UPI0000169553
XR_928319
Participant Of
input
Interaction of Tie2 with Ang1
hasComponent
ANGPT1:p-5Y,S119-TEK [plasma membrane]
ANGPT1:TEK [plasma membrane]
Inferred To
Homologues of ANGPT1 [extracellular region] (Drosophila melanogaster)
ANGPT1 [extracellular region] (Bos taurus)
ANGPT1 [extracellular region] (Canis familiaris)
ANGPT1 [extracellular region] (Danio rerio)
ANGPT1 [extracellular region] (Drosophila melanogaster)
ANGPT1 [extracellular region] (Gallus gallus)
ANGPT1 [extracellular region] (Mus musculus)
ANGPT1 [extracellular region] (Rattus norvegicus)
ANGPT1 [extracellular region] (Sus scrofa)
ANGPT1 [extracellular region] (Taeniopygia guttata)
ANGPT1 [extracellular region] (Xenopus tropicalis)
Cross References
RefSeq
NP_001300980.1
,
NP_001186788.1
,
NP_001137.2
GeneCards
Q15389
DOCK Blaster
4JYO
,
4EPU
,
4K0V
PRO
Q15389
PDB
4EPU
,
4JYO
,
4K0V
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