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N-myristoylation of eNOS
Stable Identifier
R-HSA-203611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
N-myristoylation of eNOS (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
A glycine residue (Gly2) at the N-terminus of eNOS is myristoylated, providing membrane localization.
Literature References
PubMed ID
Title
Journal
Year
7512951
Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase
Liu, J
,
Sessa, WC
J Biol Chem
1994
Participants
Input
MYS-CoA [cytosol]
NOS3 [cytosol]
(Homo sapiens)
Output
MyrG-NOS3 [cytosol]
(Homo sapiens)
Participates
as an event of
eNOS activation (Homo sapiens)
Orthologous Events
N-myristoylation of eNOS (Bos taurus)
N-myristoylation of eNOS (Dictyostelium discoideum)
N-myristoylation of eNOS (Drosophila melanogaster)
N-myristoylation of eNOS (Gallus gallus)
N-myristoylation of eNOS (Mus musculus)
N-myristoylation of eNOS (Plasmodium falciparum)
N-myristoylation of eNOS (Rattus norvegicus)
N-myristoylation of eNOS (Saccharomyces cerevisiae)
N-myristoylation of eNOS (Schizosaccharomyces pombe)
N-myristoylation of eNOS (Sus scrofa)
Authored
Hemish, J (2007-10-19)
Reviewed
Enikolopov, G (2008-02-28)
Created
Hemish, J (2007-10-19)
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