NMT1/2 transfer MYS to GNAT1

Stable Identifier
R-HSA-2534087
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, photoreceptor disc membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NMT1/2 transfer MYS to GNAT1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After removal of the N-terminal methionine (Met) residue, the enzymes glycylpeptide N-tetradecanoyltransferase 1 and 2 (NMT1 and 2) mediate the transfer of the myristoyl (MYS) group from myristoyl-CoA to the now N-terminal glycine (Gly) residue of transducin's alpha subunit (GNAT1) (Glover et al. 1997, Giang & Cravatt 1998). Myristoylation is thought to aid enzyme function and localization. Evidence from chicken experiments suggest non-myristoylated proteins do not bind to membranes (Kamps et al. 1986).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glycylpeptide N-tetradecanoyltransferase activity of NMT1/2 [cytosol]

Physical Entity
NMT1/2 [cytosol] (Homo sapiens)
Activity
glycylpeptide N-tetradecanoyltransferase activity (GO:0004379)
Orthologous Events
NMT1/2 transfer MYS to GNAT1 (Bos taurus)
NMT1/2 transfer MYS to GNAT1 (Canis familiaris)
NMT1/2 transfer MYS to GNAT1 (Danio rerio)
NMT1/2 transfer MYS to GNAT1 (Dictyostelium discoideum)
NMT1/2 transfer MYS to GNAT1 (Mus musculus)
NMT1/2 transfer MYS to GNAT1 (Rattus norvegicus)
NMT1/2 transfer MYS to GNAT1 (Saccharomyces cerevisiae)
NMT1/2 transfer MYS to GNAT1 (Schizosaccharomyces pombe)
NMT1/2 transfer MYS to GNAT1 (Sus scrofa)
NMT1/2 transfer MYS to GNAT1 (Xenopus tropicalis)
N-myristoylation of eNOS (Homo sapiens)
Authored
Jassal, B  (2012-10-23)
Reviewed
D'Eustachio, P  (2024-05-28)
Makino, C  (2013-04-11)
Created
Jassal, B  (2012-10-23)
Cite Us!