NMT1/2 transfer MYS to GNAT1

Stable Identifier
R-HSA-2534087
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, photoreceptor disc membrane
ReviewStatus
5/5
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NMT1/2 transfer MYS to GNAT1
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After removal of the N-terminal methionine (Met) residue, the enzymes glycylpeptide N-tetradecanoyltransferase 1 and 2 (NMT1 and 2) mediate the transfer of the myristoyl (MYS) group from myristoyl-CoA to the now N-terminal glycine (Gly) residue of transducin's alpha subunit (GNAT1) (Glover et al. 1997, Giang & Cravatt 1998). Myristoylation is thought to aid enzyme function and localization. Evidence from chicken experiments suggest non-myristoylated proteins do not bind to membranes (Kamps et al. 1986).
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Output
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as an event of
Catalyst Activity

glycylpeptide N-tetradecanoyltransferase activity of NMT1/2 [cytosol]

Physical Entity
NMT1/2 [cytosol] (Homo sapiens)
Activity
glycylpeptide N-tetradecanoyltransferase activity (GO:0004379)
Orthologous Events
NMT1/2 transfer MYS to GNAT1 (Bos taurus)
NMT1/2 transfer MYS to GNAT1 (Caenorhabditis elegans)
NMT1/2 transfer MYS to GNAT1 (Danio rerio)
NMT1/2 transfer MYS to GNAT1 (Dictyostelium discoideum)
NMT1/2 transfer MYS to GNAT1 (Gallus gallus)
NMT1/2 transfer MYS to GNAT1 (Mus musculus)
NMT1/2 transfer MYS to GNAT1 (Rattus norvegicus)
NMT1/2 transfer MYS to GNAT1 (Saccharomyces cerevisiae)
NMT1/2 transfer MYS to GNAT1 (Schizosaccharomyces pombe)
NMT1/2 transfer MYS to GNAT1 (Sus scrofa)
NMT1/2 transfer MYS to GNAT1 (Xenopus tropicalis)
N-myristoylation of eNOS (Homo sapiens)
Authored
Jassal, B  (2012-10-23)
Reviewed
Makino, C  (2013-04-11)
D'Eustachio, P  (2024-05-28)
Created
Jassal, B  (2012-10-23)
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