Synthesis of pyrophosphates in the cytosol

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
Inositol phosphates such as IP4, IP5 and IP6 are converted to an even wider variety of IPs including the di- and triphospho inositol phosphates, also known as pyrophosphates (Irvine & Schell 2001, Alcazar-Romain & Wente 2008, York 2006, Monserrate and York 2010, Ho et al. 2002, Saiardi et al. 2001, Draskovic et al. 2008, Choi et al. 2007, Caffrey et al. 2000, Leslie et al. 2002).
Literature References
PubMed ID Title Journal Year
20359876 Inositol phosphate synthesis and the nuclear processes they affect

Monserrate, JP, York, JD

Curr Opin Cell Biol 2010
17943301 Inositol polyphosphates: a new frontier for regulating gene expression

Wente, SR, Alcázar-Román, AR

Chromosoma 2008
11331907 Back in the water: the return of the inositol phosphates

Schell, MJ, Irvine, RF

Nat Rev Mol Cell Biol 2001
18355727 Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups

Ilc, G, Bhandari, R, Burton, A, Kovacevic, M, Saiardi, A, Podobnik, M, Snyder, SH, Draskovic, P

Chem Biol 2008
12121577 Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases

Safrany, ST, Leslie, NR, McLennan, AG

BMC Biochem 2002
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Nagata, E, Saiardi, A, Snyder, SH, Snowman, AM, Luo, HR

J Biol Chem 2001
10777568 Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family

Safrany, ST, Caffrey, JJ, Yang, X, Shears, SB

J Biol Chem 2000
17702752 Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress

Cho, J, Williams, J, Falck, JR, Choi, JH, Shears, SB

J Biol Chem 2007
16781889 Regulation of nuclear processes by inositol polyphosphates

York, JD

Biochim Biophys Acta 2006
11909533 Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase

Zhang, T, Kwon, YU, Potter, BV, Carew, MA, Chung, SK, Riley, AM, Vogel, G, Hua, L, Ho, MW, Yang, X, Shears, SB, Adelt, S

Curr Biol 2002
Event Information
Orthologous Events
Cite Us!