eNOS synthesizes NO

Stable Identifier
R-HSA-202127
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
NO biosynthesis
Locations in the PathwayBrowser
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Nitric oxide (NO) is produced from L-arginine by the family of nitric oxide synthases (NOS) enzymes, forming the free radical NO and citrulline as byproduct. The cofactor tetrahydrobiopterin (BH4) is an essential requirement for the delivery of an electron to the intermediate in the catalytic cycle of NOS.

Literature References
PubMed ID Title Journal Year
7526779 Nitric oxide: a physiologic messenger molecule

Bredt, DS, Snyder, SH

Annu Rev Biochem 1994
15467163 Nitric Oxide as a Unique Bioactive Signaling Messenger in Physiology and Pathophysiology

Tuteja, N, Chandra, M, Tuteja, R, Misra, MK

J Biomed Biotechnol 2004
8782602 Determination of nitric oxide synthase cofactors: heme, FAD, FMN, and tetrahydrobiopterin

Klatt, P, Schmidt, K, Werner, ER, Mayer, B

Methods Enzymol 1996
9173876 Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization

List, BM, Klosch, B, Volker, C, Gorren, AC, Sessa, WC, Werner, ER, Kukovetz, WR, Schmidt, K, Mayer, B

Biochem J 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nitric-oxide synthase activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created