eNOS synthesizes NO

Stable Identifier
Reaction [transition]
Homo sapiens
NO biosynthesis
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Nitric oxide (NO) is produced from L-arginine by the family of nitric oxide synthases (NOS) enzymes, forming the free radical NO and citrulline as byproduct. The cofactor tetrahydrobiopterin (BH4) is an essential requirement for the delivery of an electron to the intermediate in the catalytic cycle of NOS.

Literature References
PubMed ID Title Journal Year
15467163 Nitric Oxide as a Unique Bioactive Signaling Messenger in Physiology and Pathophysiology

Misra, MK, Tuteja, N, Chandra, M, Tuteja, R

J Biomed Biotechnol 2004
7526779 Nitric oxide: a physiologic messenger molecule

Snyder, SH, Bredt, DS

Annu Rev Biochem 1994
8782602 Determination of nitric oxide synthase cofactors: heme, FAD, FMN, and tetrahydrobiopterin

Schmidt, K, Werner, ER, Mayer, B, Klatt, P

Methods Enzymol 1996
9173876 Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization

Sessa, WC, Schmidt, K, Volker, C, Gorren, AC, Werner, ER, List, BM, Mayer, B, Kukovetz, WR, Klosch, B

Biochem J 1997
Catalyst Activity

nitric-oxide synthase activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]

This event is regulated
Negatively by
Orthologous Events
Cite Us!