Caspase-mediated cleavage of plakophilin-1

Stable Identifier
R-HSA-201595
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Desmosomes represent one of the anchoring junctions mediating strong cell-cell contacts.Desmosomal plaque proteins including the head domain of plakophilin provide interaction sites for cytokeratin filaments (see references in Weiske et al.,2001). Proteolytic fragmentation of these proteins prevents binding of intermediate filaments and in consequence results in remodeling of the intermediate filament cytoskeleton (Weiske et al., 2001).Cleaved Plakophilin-1 appears to be impaired in supporting the formation and maintenance of desmosomes during apoptosis (Weiske et al., 2001). Caspase-3 inhibition prevents cleavage of Plakophilin-1, implicating Caspase-3 as the responsible endopeptidase (Weiske et al. 2001).

Literature References
PubMed ID Title Journal Year
11500511 The fate of desmosomal proteins in apoptotic cells

Weiske, J, Schoneberg, T, Schroder, W, Hatzfeld, M, Tauber, R, Huber, O

J Biol Chem 2001
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Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Activity
Orthologous Events
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Created