Reactome | PKP1 [plasma membrane]

PKP1 [plasma membrane]

Stable Identifier

R-SSC-201597

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

PKP1, I3LGN8

Locations in the PathwayBrowser

Expand all

Developmental Biology (Sus scrofa)

- Keratinization (Sus scrofa)
  - Formation of the cornified envelope (Sus scrofa)
    - CASP14 cleaves filaggrin (Sus scrofa)
      - Late cornified envelope [plasma membrane] (Sus scrofa)
        
        Cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
      - Mature cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        No FGN-Cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-late cornified envelope [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
    - CDSN binds the cornified envelope (Sus scrofa)
      - Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
      - Cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
    - Filaggrin binds Keratin tonofilament:Desmosome (Sus scrofa)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
      - Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
    - Fillagrin and keratin intermediate filaments polymerize forming a network (Sus scrofa)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
      - FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
    - Lamellar bodies bind the early cornified envelope (Sus scrofa)
      - Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
      - Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
    - PERP binds desmosomes (Sus scrofa)
      - Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
      - Desmosome:PERP [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
    - Plasma membrane resorption (Sus scrofa)
      - Mature cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        No FGN-Cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-late cornified envelope [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
  - Keratin filaments bind cell-cell adhesion complexes (Sus scrofa)
    - Desmosome [plasma membrane] (Sus scrofa)
      - Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)
    - Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
      - Desmosome [plasma membrane] (Sus scrofa)
        
        Plakophilins [plasma membrane] (Sus scrofa)
        
        PKP1 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3LGN8

Gene Names

PKP1

Reference Genes

BioGPS Gene:100623590 PKP1

ENSEMBL:ENSSSCG00000030694.3

KEGG:ssc:100623590 PKP1

Monarch:100623590 PKP1

NCBI Gene:100623590 PKP1

UCSC:I3LGN8 PKP1

Reference Transcript

RefSeq:XM_021064508.1 PKP1

Other Identifiers

100623590

GO:0001533

GO:0002159

GO:0002160

GO:0003677

GO:0003723

GO:0005515

GO:0005521

GO:0005634

GO:0005654

GO:0005737

GO:0005886

GO:0005912

GO:0006355

GO:0007010

GO:0007155

GO:0010494

GO:0010628

GO:0016020

GO:0022409

GO:0030057

GO:0034330

GO:0035377

GO:0036305

GO:0043226

GO:0045110

GO:0045296

GO:0045618

GO:0045944

GO:0048471

GO:0070161

GO:0097165

GO:0098609

GO:1902373

GO:1903078

GO:1903676

GO:1905477

Ssc.2963.1.S1_at

Participates

as a member of

as an input of

Caspase-mediated cleavage of plakophilin-1 (Sus scrofa)

Other forms of this molecule

PKP1 [cornified envelope]

PKP1 [ficolin-1-rich granule membrane]

PKP1 [plasma membrane]

Inferred From

PKP1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_020920167.1

ENSEMBL

ENSSSCT00000038415, ENSSSCG00000030694, ENSSSCP00000033883

VGNC

96487

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