After high-affinity ligand binding, FGFR3 P250R is believed to undergo trans-autophosphorylation in a manner analogous to the wild-type receptor, although this remains to be experimentally validated (Ibrahimi, 2004a).
Eliseenkova, AV, Linhardt, RJ, Zhang, F, Mohammadi, M, Ibrahimi, OA
protein tyrosine kinase activity of FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
Gain of function of FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
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