PANK1/3 phosphorylate PanK

Stable Identifier
Reaction [transition]
Homo sapiens
(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+), Pantothenate is phosphorylated [PANK1;3;4]
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Cytosolic pantothenate kinases 1 and 3 (PANK1, PANK3) catalyze the reaction of ATP and pantothenate to form ADP and phosphopantothenate. This enzymatic activity has been demonstrated in crude cell extracts for two isoforms of mouse pantothenate kinase 1 (Rock et al. 2002) and for their human homologues (Ramaswamy and 2004). An additional human gene, PANK3, encodes a closely related protein but pantothenate kinase activity has not been demonstrated experimentally for it (Cavestro et al. 2023; Leonardi et al. 2005; Zhou et al. 2001).
Literature References
PubMed ID Title Journal Year
15893380 Coenzyme A: back in action

Leonardi, R, Zhang, YM, Rock, CO, Jackowski, S

Prog Lipid Res 2005
12095677 The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes

Zhang, YM, Rock, CO, Jackowski, S, Karim, MA

Gene 2002
11479594 A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

Hayflick, SJ, Johnson, MA, Zhou, B, Levinson, B, Westaway, SK, Gitschier, J

Nat Genet 2001
14523052 PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression

Ramaswamy, G, Murti, KG, Jackowski, S, Karim, MA

J Lipid Res 2004
36983025 Inherited Disorders of Coenzyme A Biosynthesis: Models, Mechanisms, and Treatments

Diodato, D, Di Meo, I, Cavestro, C, Tiranti, V

Int J Mol Sci 2023
Catalyst Activity

pantothenate kinase activity of PANK1/3 [cytosol]

Orthologous Events
Cross References
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