PANK1/3/4 phosphorylate PanK

Stable Identifier
R-HSA-199203
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Pantothenate is phosphorylated [PANK1;3;4], pantothenate + ATP => phosphopanthothenate + ADP
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Cytosolic pantothenate kinases catalyze the reaction of ATP and pantothenate to form ADP and phosphopantothenate. This enzymatic activity has been demonstrated in crude cell extracts for two isoforms of mouse pantothenate kinase 1 (Rock et al. 2002) and for their human homologues (Ramaswamy and 2004). Two additional human genes, PANK3 and PANK4, encode closely related proteins but pantothenate kinase activity has not been demonstrated experimentally for them (Leonardi et al. 2005; Zhou et al. 2001).

Literature References
PubMed ID Title Journal Year
14523052 PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression

Ramaswamy, G, Karim, MA, Murti, KG, Jackowski, S

J Lipid Res 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
pantothenate kinase activity of PANK1/3/4 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created
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