Coenzyme A biosynthesis

Stable Identifier
Homo sapiens
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Coenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle (Lipmann 1953). It is synthesized from the vitamin pantothenate in a sequence of five reactions (Daugherty et al. 2002; Leonardi et al. 2005; Robishaw and Neely 1985). These reactions all occur in the cytosol or the mitochondrial intermembrane space (Leonardi et al. 2005). A recently described transport protein appears to mediate the uptake of Coenzyme A into the mitochondrial matrix (Prohl et al. 2001).

Literature References
PubMed ID Title Journal Year
15893380 Coenzyme A: back in action

Leonardi, R, Zhang, YM, Rock, CO, Jackowski, S

Prog Lipid Res 2005
11158296 The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix

Prohl, C, Pelzer, W, Diekert, K, Kmita, H, Bedekovics, T, Kispal, G, Lill, R

Mol Cell Biol 2001
13032008 On chemistry and function of coenzyme A

Lipmann, F

Bacteriol Rev 1953
2981478 Coenzyme A metabolism

Robishaw, JD, Neely, JR

Am J Physiol 1985
11923312 Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics

Daugherty, M, Polanuyer, B, Farrell, M, Scholle, M, Lykidis, A, de Crecy-Lagard, V, Osterman, A

J Biol Chem 2002
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