Expression of CTGF

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The CTGF gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of the CTGF gene is increased by both YAP1:TEAD and WWTR1(TAZ):TEAD transcriptional coactivator:transcription factor complexes, so that CTGF is one of the many genes whose expression is downregulated by the action of the hippo cascade (Zhang et al. 2009; Zhao et al. 2008).

Literature References
PubMed ID Title Journal Year
20110263 Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis

de Groot, PJ, de Vries, SC, Kersten, S, van der Meer, DL, Vaisanen, S, Carlberg, C, Muller, M, Heinaniemi, M, Degenhardt, T

Nucleic Acids Res 2010
18579750 TEAD mediates YAP-dependent gene induction and growth control

Guan, KL, Yu, J, Li, L, Li, S, Li, W, Ye, X, Chinnaiyan, AM, Wang, CY, Lai, ZC, Yu, J, Zhao, B, Lin, JD

Genes Dev. 2008
19324877 TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition

Lei, Q, Guan, KL, Xiong, Y, Liu, CY, Zhang, H, Zhao, B, Zha, ZY, Yao, J, Zhao, S

J Biol Chem 2009
19324876 TEADs mediate nuclear retention of TAZ to promote oncogenic transformation

Lim, CJ, Hong, W, Loo, LS, Huang, C, Chan, SW, Chong, YF

J Biol Chem 2009
This event is regulated
Positively by