RUNX3 regulates YAP1-mediated transcription

Stable Identifier
R-HSA-8951671
Type
Pathway
Species
Homo sapiens
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Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter, thus negatively regulating transcription of the CTGF gene which encodes the Connective tissue growth factor (Yagi et al. 1999, Zhao et al. 2008, Qiao et al. 2016).

Literature References
PubMed ID Title Journal Year
10228168 A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

Chen, LF, Ito, Y, Yagi, R, Murakami, Y, Shigesada, K

EMBO J. 1999
18579750 TEAD mediates YAP-dependent gene induction and growth control

Guan, KL, Yu, J, Li, L, Li, S, Li, W, Ye, X, Chinnaiyan, AM, Wang, CY, Lai, ZC, Yu, J, Zhao, B, Lin, JD

Genes Dev. 2008
26364597 RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer

Tan, P, Lin, SJ, Voon, DC, Chuang, LS, Yeoh, KG, Wang, T, Qiao, Y, Sudol, M, Ito, Y, Lee, SC, Chen, Y, Zhu, F

Oncogene 2016
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