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TRBV12-3 [plasma membrane]
Stable Identifier
R-HSA-198181
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
T-cell receptor beta chain V region YT35 precursor, TVB1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
PD-1 signaling (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)
CD1:B2M:microbial lipid:TCR [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
TCR binds self-lipid-based antigen via CD1 (Homo sapiens)
CD1:B2M:self-lipid:TCR [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)
T-cell receptor complex with CD8 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Homo sapiens)
T-cell receptor complex with CD8 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Change of PKC theta conformation (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Phosphorylation of PLC-gamma1 (Homo sapiens)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Phosphorylation of TBSMs in LAT (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Activation of Lck (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Inactivation of LCK by PTPN22 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Inactivation of Lck by Csk (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Activation of ZAP-70 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
PTPN22 dephosphorylates ZAP70 (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Phosphorylation of ZAP-70 by Lck (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain beta [plasma membrane] (Homo sapiens)
TRBV12-3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01733 TRBV12-3
Gene Names
TRBV12-3, TCRBV12S3, TCRBV8S1
Chain
signal peptide:1-21, chain:22-115
Reference Genes
ENSEMBL:ENSG00000274752 TRBV12-3
ENSEMBL_homo_sapiens_GENE:ENSG00000274752.1 TRBV12-3
ENSEMBL_homo_sapiens_GENE:ENSG00000282208.1 TRBV12-3
HGNC:12185 TRBV12-3
Other Identifiers
3028409
3028410
3028411
3028412
3028413
3028415
GO:0002250
GO:0002376
GO:0005886
GO:0006955
GO:0007166
GO:0016020
GO:0023052
GO:0042101
GO:0042287
GO:0042605
Participates
as a member of
TCR chain beta [plasma membrane] (Homo sapiens)
Inferred To
Homologues of TRBV12-3 [plasma membrane]
(Bos taurus)
Homologues of TRBV12-3 [plasma membrane]
(Mus musculus)
Homologues of TRBV12-3 [plasma membrane]
(Rattus norvegicus)
Homologues of TRBV12-3 [plasma membrane]
(Sus scrofa)
TRBV12-3 [plasma membrane]
(Bos taurus)
TRBV12-3 [plasma membrane]
(Canis familiaris)
TRBV12-3 [plasma membrane]
(Sus scrofa)
Trbv15 [plasma membrane]
(Mus musculus)
ENSRNOG00000065908 [plasma membrane]
(Rattus norvegicus)
Trbv16 [plasma membrane]
(Mus musculus)
Trbv16 [plasma membrane]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000274752
GeneCards
P01733
HPA
ENSG00000274752-TRBV12-3
Ensembl
ENSG00000282208
,
ENSP00000487964
,
ENSG00000274752
,
ENSP00000477916
,
ENST00000633292
,
ENST00000620569
PRO
P01733
Pharos - Targets
P01733
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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