Reactome | Trbv15 [plasma membrane]

Trbv15 [plasma membrane]

Stable Identifier

R-MMU-198181

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

TRBV12-3, A0A0A6YYE3

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Costimulation by the CD28 family (Mus musculus)
    - PD-1 signaling (Mus musculus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Mus musculus)
    - TCR binds microbial lipid-based antigen via CD1 (Mus musculus)
      - CD1:B2M:microbial lipid:TCR [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
    - TCR binds self-lipid-based antigen via CD1 (Mus musculus)
      - CD1:B2M:self-lipid:TCR [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Mus musculus)
      - T-cell receptor complex with CD8 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with CD8 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
  - TCR signaling (Mus musculus)
    - Downstream TCR signaling (Mus musculus)
      - Change of PKC theta conformation (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
    - Generation of second messenger molecules (Mus musculus)
      - Phosphorylation of PLC-gamma1 (Mus musculus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - Phosphorylation of SLP-76 (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - Phosphorylation of TBSMs in LAT (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
    - Phosphorylation of CD3 and TCR zeta chains (Mus musculus)
      - Activation of Lck (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - Inactivation of LCK by PTPN22 (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - Inactivation of Lck by Csk (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
    - Translocation of ZAP-70 to Immunological synapse (Mus musculus)
      - Activation of ZAP-70 (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - PTPN22 dephosphorylates ZAP70 (Mus musculus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - Phosphorylation of ZAP-70 by Lck (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        T-cell receptor [plasma membrane] (Mus musculus)
        
        Homologues of TRBV12-3 [plasma membrane] (Mus musculus)
        
        Trbv15 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:A0A0A6YYE3

Gene Names

Trbv15

Reference Genes

ENSEMBL:ENSMUSG00000076472

ENSEMBL:ENSMUSG00000076472.3 Trbv15

Other Identifiers

17457703

4426275

4459273

4671793

5083181

5285910

5535288

5568105

A_52_P557517

GO:0005886

GO:0007166

GO:0023052

ILMN_1259713

Participates

as a member of

Homologues of TRBV12-3 [plasma membrane] (Mus musculus)

Inferred From

TRBV12-3 [plasma membrane] (Homo sapiens)

Cross References

Ensembl

ENSMUST00000103273, ENSMUSP00000100089, ENSMUSG00000076472

MGI

98586

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