Reactome | NOTCH1 binds DLL/JAG ligand in cis

NOTCH1 binds DLL/JAG ligand in cis

Stable Identifier

R-HSA-1980138

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Binding of NOTCH1 to DLL/JAG ligands expressed in the same cells (in cis) blocks NOTCH1 activation by DLL/JAG ligands expressed on neighboring cells (in trans). Cis-inhibiton of NOTCH signaling can amplify small differences in NOTCH and DLL/JAG levels between neighboring cells.

Literature References

PubMed ID	Title	Journal	Year
18660822	A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition Tay, JZ, Wilkin, MB, Lea, SM, Whiteman, P, Redfield, C, Cordle, J, Handford, PA, Baron, M, Hernandez de Madrid Diaz, B, Jin, B, Jensen, S, Johnson, S, Roversi, P, Shimizu, H	Nat Struct Mol Biol	2008
20418862	Cis-interactions between Notch and Delta generate mutually exclusive signalling states Sprinzak, D, Garcia-Ojalvo, J, Santat, LA, Fontes, ME, LeBon, L, Lakhanpal, A, Elowitz, MB, Anderson, GA	Nature	2010