Binding of NOTCH1 to DLL/JAG ligands expressed in the same cells (in cis) blocks NOTCH1 activation by DLL/JAG ligands expressed on neighboring cells (in trans). Cis-inhibiton of NOTCH signaling can amplify small differences in NOTCH and DLL/JAG levels between neighboring cells.
Sprinzak, D, Lakhanpal, A, LeBon, L, Santat, LA, Fontes, ME, Anderson, GA, Garcia-Ojalvo, J, Elowitz, MB
Cordle, J, Johnson, S, Tay, JZ, Roversi, P, Wilkin, MB, Hernandez de Madrid Diaz, B, Shimizu, H, Jensen, S, Whiteman, P, Jin, B, Redfield, C, Baron, M, Lea, SM, Handford, PA
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