Binding of NOTCH1 to DLL/JAG ligands expressed in the same cells (in cis) blocks NOTCH1 activation by DLL/JAG ligands expressed on neighboring cells (in trans). Cis-inhibiton of NOTCH signaling can amplify small differences in NOTCH and DLL/JAG levels between neighboring cells.
Tay, JZ, Wilkin, MB, Lea, SM, Whiteman, P, Redfield, C, Cordle, J, Handford, PA, Baron, M, Hernandez de Madrid Diaz, B, Jin, B, Jensen, S, Johnson, S, Roversi, P, Shimizu, H
Sprinzak, D, Garcia-Ojalvo, J, Santat, LA, Fontes, ME, LeBon, L, Lakhanpal, A, Elowitz, MB, Anderson, GA
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