NOTCH1 binds DLL/JAG ligand in cis

Stable Identifier
R-HSA-1980138
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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NOTCH1 binds DLL/JAG ligand in cis
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Binding of NOTCH1 to DLL/JAG ligands expressed in the same cells (in cis) blocks NOTCH1 activation by DLL/JAG ligands expressed on neighboring cells (in trans). Cis-inhibiton of NOTCH signaling can amplify small differences in NOTCH and DLL/JAG levels between neighboring cells. These findings are based on studies conducted in Drosophila (Cordle et al. 2008) and in mammalian cell culture where human NOTCH1 and rat Dll1 were used (Sprinzak et al. 2010).
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Inferred From
Serrate binds Notch in cis (Drosophila melanogaster)
rDll1 binds NOTCH1 in cis (Homo sapiens)
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-09)
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