Cleavage of DNER:NOTCH1 complex releases NICD1

Stable Identifier
R-HSA-1980112
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Cleavage of DNER:NOTCH1 complex releases NICD1
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Binding of DNER to NOTCH1 induces gamma-secretase dependent cleavage of NOTCH1 at the S3 cleavage site and releases NOTCH1 intracellular domain into the cytosol. Cleavage of NOTCH1 at the S2 cleavage site by ADAM10/17, which should precede cleavage at the S3 site, has not been studied in the context of DNER-mediated NOTCH1 activation.
Literature References
PubMed ID Title Journal Year
15965470 DNER acts as a neuron-specific Notch ligand during Bergmann glial development

Kengaku, M, Eiraku, M, Ono, K, Kaneko, M, Fujishima, K, Tohgo, A, Hirano, T

Nat Neurosci 2005
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
This event is regulated
Positively by
Regulator
gamma-secretase complex [plasma membrane] (Homo sapiens)
Inferred From
Gamma secretase cleaves Dner:Notch1 complex (Mus musculus)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-09)
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