Reactome | IL1RL1 [plasma membrane]

IL1RL1 [plasma membrane]

Stable Identifier

R-HSA-197594

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-1 receptor-like 1, IRL1_HUMAN, ST2, IL-33R alpha, IL-1R4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
        
        IL1RL1:IL33 [plasma membrane] (Homo sapiens)
        
        IL1RL1 [plasma membrane] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
        
        IL1RL1:IL33 [plasma membrane] (Homo sapiens)
        
        IL1RL1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01638 IL1RL1

Gene Names

IL1RL1, DER4, ST2, T1

Chain

signal peptide:1-18, chain:19-556

Reference Genes

BioGPS Gene:9173 IL1RL1

COSMIC (genes):IL1RL1 IL1RL1

CTD Gene:9173 IL1RL1

dbSNP Gene:9173 IL1RL1

ENSEMBL:ENSG00000115602 IL1RL1

HGNC:5998 IL1RL1

KEGG:hsa:9173 IL1RL1

Monarch:9173 IL1RL1

NCBI Gene:9173 IL1RL1

OMIM:601203 IL1RL1

UCSC:Q01638 IL1RL1

Reference Transcript

Participates

as an input of

IL33 binds IL1RL1 (Homo sapiens)

as a component of

IL1RL1:IL33 [plasma membrane] (Homo sapiens)

Inferred To

Il1rl1 [plasma membrane] (Mus musculus)

Il1rl1 [plasma membrane] (Rattus norvegicus)

IL1RL1 [plasma membrane] (Bos taurus)

IL1RL1 [plasma membrane] (Gallus gallus)

IL1RL1 [plasma membrane] (Sus scrofa)

Ghost homologue of IL1RL1 [plasma membrane] (Canis familiaris)

Cross References

RefSeq

NP_001269337.1, XP_006712902.1, NP_057316.3, XP_011510453.1, NP_003847.2

Guide to Pharmacology - Targets

1735

ENSEMBL

ENST00000233954, ENST00000404917, ENSP00000233954, ENST00000311734, ENST00000427077, ENSP00000384822, ENSP00000391120, ENSG00000115602, ENSP00000310371

OpenTargets

ENSG00000115602

GeneCards

IL1RL1

HPA

ENSG00000115602-IL1RL1

PRO

Q01638

Pharos - Targets

Q01638

HMDB Protein

HMDBP12408

PDB

4KC3

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXN2 CLEC7A	2	p-Y15-CLEC7A [plasma membrane] (R-HSA-5607641) CLEC7A [plasma membrane] (R-HSA-2130683)	0.556	3