Reactome | IL1RL1 [plasma membrane]

IL1RL1 [plasma membrane]

Stable Identifier

R-HSA-197594

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-1 receptor-like 1, IRL1_HUMAN, ST2, IL-33R alpha, IL-1R4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
        
        IL1RL1:IL33 [plasma membrane] (Homo sapiens)
        
        IL1RL1 [plasma membrane] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
        
        IL1RL1:IL33 [plasma membrane] (Homo sapiens)
        
        IL1RL1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01638 IL1RL1

Gene Names

IL1RL1, DER4, ST2, T1

Chain

signal peptide:1-18, chain:19-556

Reference Genes

BioGPS Gene:9173 IL1RL1

COSMIC (genes):IL1RL1 IL1RL1

CTD Gene:9173 IL1RL1

dbSNP Gene:9173 IL1RL1

ENSEMBL:ENSG00000115602 IL1RL1

HGNC:5998 IL1RL1

KEGG Gene (Homo sapiens):9173 IL1RL1

Monarch:9173 IL1RL1

NCBI Gene:9173 IL1RL1

OMIM:601203 IL1RL1

UCSC:Q01638 IL1RL1

Reference Transcript

Other Identifiers

0002350348

0004200672

0006620731

11734884_a_at

11734885_at

11738178_at

11745596_a_at

11759145_s_at

16883690

207526_s_at

210442_at

234066_at

242809_at

2497083

2497087

2497089

2497090

2497091

2497093

2497094

2497095

2497096

2497098

2497099

2497101

2497102

2497103

2497104

2497105

2497106

2497107

2497108

2497109

2497110

2497111

40321_at

40322_at

49715_r_at

73561_at

75423_at

8044021

9173

A_14_P118105

A_23_P51126

A_33_P3211608

D12763_at

GE53322

GO:0002113

GO:0002114

GO:0002376

GO:0002826

GO:0003674

GO:0003953

GO:0004896

GO:0004908

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0005925

GO:0006950

GO:0006955

GO:0007165

GO:0008150

GO:0009897

GO:0016020

GO:0016021

GO:0016787

GO:0016798

GO:0032689

GO:0032722

GO:0032754

GO:0038172

GO:0043032

GO:0050135

GO:0050729

GO:0061809

HMNXSV003045938

HMNXSV003051094

Hs.117037.0.A1_3p_at

Hs.296502.0.S1_3p_at

ILMN_1697444

ILMN_1788623

ILMN_2242900

ILMN_2313672

PH_hs_0000011

TC02003446.hg

TC02004994.hg

g4507244_3p_a_at

g6714554_3p_at

Participates

as an input of

IL33 binds IL1RL1 (Homo sapiens)

as a component of

IL1RL1:IL33 [plasma membrane] (Homo sapiens)

Inferred To

Il1rl1 [plasma membrane] (Mus musculus)

Il1rl1 [plasma membrane] (Rattus norvegicus)

IL1RL1 [plasma membrane] (Canis familiaris)

IL1RL1 [plasma membrane] (Gallus gallus)

IL1RL1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_011510453.1, NP_003847.2, NP_057316.3, XP_006712902.1, NP_001269337.1

Guide to Pharmacology - Targets

1735

OpenTargets

ENSG00000115602

GeneCards

Q01638

HPA

ENSG00000115602-IL1RL1

Ensembl

ENSP00000391120, ENST00000233954, ENSP00000384822, ENSP00000310371, ENSG00000115602, ENST00000311734, ENSP00000233954, ENST00000427077, ENST00000404917

PRO

Q01638

Pharos - Targets

Q01638

GlyGen

Q01638

PDB

4KC3

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXN2 CLEC7A	2	p-Y15-CLEC7A [plasma membrane] (R-HSA-5607641) CLEC7A [plasma membrane] (R-HSA-2130683)	0.556	3