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IL1RL1 [plasma membrane]
Stable Identifier
R-HSA-197594
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-1 receptor-like 1, IRL1_HUMAN, ST2, IL-33R alpha, IL-1R4
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-33 signaling (Homo sapiens)
IL33 binds IL1RL1 (Homo sapiens)
IL1RL1 [plasma membrane] (Homo sapiens)
IL1RL1:IL33 [plasma membrane] (Homo sapiens)
IL1RL1 [plasma membrane] (Homo sapiens)
IL33:IL1RL1 binds IL1RAP-1 (Homo sapiens)
IL1RL1:IL33 [plasma membrane] (Homo sapiens)
IL1RL1 [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1RL1:IL33 [plasma membrane] (Homo sapiens)
IL1RL1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1RL1:IL33 [plasma membrane] (Homo sapiens)
IL1RL1 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1RL1:IL33 [plasma membrane] (Homo sapiens)
IL1RL1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01638 IL1RL1
Gene Names
IL1RL1, DER4, ST2, T1
Chain
signal peptide:1-18, chain:19-556
Reference Genes
BioGPS Gene:9173 IL1RL1
COSMIC (genes):IL1RL1 IL1RL1
CTD Gene:9173 IL1RL1
dbSNP Gene:9173 IL1RL1
ENSEMBL:ENSG00000115602 IL1RL1
HGNC:5998 IL1RL1
KEGG:hsa:9173 IL1RL1
Monarch:9173 IL1RL1
NCBI Gene:9173 IL1RL1
OMIM:601203 IL1RL1
UCSC:Q01638 IL1RL1
Reference Transcript
RefSeq:NM_003856.3 IL1RL1
RefSeq:XM_006712839.3 IL1RL1
RefSeq:XM_011512151.1 IL1RL1
RefSeq:NM_001282408.1 IL1RL1
RefSeq:NM_016232.4 IL1RL1
Participates
as an input of
IL33 binds IL1RL1 (Homo sapiens)
as a component of
IL1RL1:IL33 [plasma membrane] (Homo sapiens)
Inferred To
Il1rl1 [plasma membrane]
(Mus musculus)
Il1rl1 [plasma membrane]
(Rattus norvegicus)
IL1RL1 [plasma membrane]
(Bos taurus)
IL1RL1 [plasma membrane]
(Gallus gallus)
IL1RL1 [plasma membrane]
(Sus scrofa)
Ghost homologue of IL1RL1 [plasma membrane]
(Canis familiaris)
Cross References
RefSeq
NP_001269337.1
,
XP_006712902.1
,
NP_057316.3
,
XP_011510453.1
,
NP_003847.2
Guide to Pharmacology - Targets
1735
ENSEMBL
ENST00000233954
,
ENST00000404917
,
ENSP00000233954
,
ENST00000311734
,
ENST00000427077
,
ENSP00000384822
,
ENSP00000391120
,
ENSG00000115602
,
ENSP00000310371
OpenTargets
ENSG00000115602
GeneCards
IL1RL1
HPA
ENSG00000115602-IL1RL1
PRO
Q01638
Pharos - Targets
Q01638
HMDB Protein
HMDBP12408
PDB
4KC3
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BXN2 CLEC7A
2
p-Y15-CLEC7A [plasma membrane]
(R-HSA-5607641)
CLEC7A [plasma membrane]
(R-HSA-2130683)
0.556
3
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