3xPPCDC:3FMN decarboxylates PPC

Stable Identifier
R-HSA-196840
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Phosphopantothenoylcysteine is decarboxylated
Locations in the PathwayBrowser
General
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The decarboxylation of phosphopantothenoylcysteine (PPC) to 4'-phosphopantetheine (PPANT) is carried out by phosphopantothenoylcysteine decarboxylase (PPCDC). PPCDC is cytosolic and exists as a homotrimer, binding one FMN cofactor per subunit. While a second isoform has been inferred from large-scale sequnceing studies, it lacks the protein's FMN-binding domain and would thus appear to be nonfunctional if it is expressed.

Literature References
PubMed ID Title Journal Year
15581364 Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent

Strauss, E, Zhai, H, Brand, LA, McLafferty, FW, Begley, TP

Biochemistry 2004
11923312 Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics

Daugherty, M, Polanuyer, B, Farrell, M, Scholle, M, Lykidis, A, de Crecy-Lagard, V, Osterman, A

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphopantothenoylcysteine decarboxylase activity of 3xPPCDC:3xFMN [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created
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