Reactome | Reduction of isocaproaldehyde to 4-methylpentan-1-ol

Reduction of isocaproaldehyde to 4-methylpentan-1-ol

Stable Identifier

R-HSA-196060

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

isocaproaldehyde + NADPH + H+ => 4-methylpentan-1-ol + NADP+

ReviewStatus

5/5

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Reduction of isocaproaldehyde to 4-methylpentan-1-ol

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Isocaproaldehyde is reduced by NADPH + H+ to yield 4-methylpentan-1-ol and NADP+. This cytosolic reaction is catalyzed by AKR1B1 (aldose reductase). The purified human enzyme has been shown to catalyze this reaction efficiently in vitro; its abundance in adrenal tissue in humans and other mammals and its concordant expression with other enzymes of steroid hormone synthesis are consistent with it performing this role in vivo as well (Matsuura et al. 1996; Lefrancois-Martinez et al. 2004). The metabolic fate of 4-methylpentan-1-ol is unknown.

Literature References

PubMed ID	Title	Journal	Year
8645003	Aldose reductase is a major reductase for isocaproaldehyde, a product of side-chain cleavage of cholesterol, in human and animal adrenal glands Hara, A, Bunai, Y, Ohya, I, Matsuura, K, Deyashiki, Y	Arch Biochem Biophys	1996