Reduction of isocaproaldehyde to 4-methylpentan-1-ol

Stable Identifier
R-HSA-196060
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
isocaproaldehyde + NADPH + H+ => 4-methylpentan-1-ol + NADP+
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Isocaproaldehyde is reduced by NADPH + H+ to yield 4-methylpentan-1-ol and NADP+. This cytosolic reaction is catalyzed by AKR1B1 (aldose reductase). The purified human enzyme has been shown to catalyze this reaction efficiently in vitro; its abundance in adrenal tissue in humans and other mammals and its concordant expression with other enzymes of steroid hormone synthesis are consistent with it performing this role in vivo as well (Matsuura et al. 1996; Lefrancois-Martinez et al. 2004). The metabolic fate of 4-methylpentan-1-ol is unknown.

Literature References
PubMed ID Title Journal Year
8645003 Aldose reductase is a major reductase for isocaproaldehyde, a product of side-chain cleavage of cholesterol, in human and animal adrenal glands

Matsuura, K, Deyashiki, Y, Bunai, Y, Ohya, I, Hara, A

Arch Biochem Biophys 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alditol:NADP+ 1-oxidoreductase activity of AKR1B1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created
Cite Us!