Reactome | RHOC [cytosol]

RHOC [cytosol]

Stable Identifier

R-HSA-194853

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RhoC

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOC GTPase cycle (Homo sapiens)
        
        GDIs block activation of RHOC (Homo sapiens)
        
        RHOC:GDP:ARHGDIA [cytosol] (Homo sapiens)
        
        RHOC:GDP [cytosol] (Homo sapiens)
        
        RHOC [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08134 RHOC

Gene Names

RHOC, ARH9, ARHC

Chain

chain:1-190, propeptide:191-193

Reference Genes

BioGPS Gene:389 RHOC

COSMIC (genes):RHOC RHOC

CTD Gene:389 RHOC

dbSNP Gene:389 RHOC

ENSEMBL:ENSG00000155366 RHOC

HGNC:669 RHOC

KEGG:hsa:389 RHOC

Monarch:389 RHOC

NCBI Gene:389 RHOC

OMIM:165380 RHOC

UCSC:P08134 RHOC

Reference Transcript

Other Identifiers

11720791_a_at

11744352_x_at

11757578_x_at

1395_at

16690974

200885_PM_at

200885_at

2428402

2428404

2428406

2428407

2428408

2428409

2428410

2428411

2428412

2428413

2428414

2428415

2428416

2428417

2428418

2428419

2428420

2428421

2428422

2428424

389

74701_at

7918593

89924_at

A_23_P12514

A_23_P406424

GE61156

GO:0000281

GO:0000910

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005634

GO:0005789

GO:0005829

GO:0005886

GO:0007015

GO:0007165

GO:0007264

GO:0016020

GO:0016787

GO:0019901

GO:0030335

GO:0031334

GO:0032154

GO:0032420

GO:0032956

GO:0034330

GO:0043123

GO:0043226

GO:0043297

GO:0044319

GO:0048870

GO:0051496

GO:0060193

GO:0070062

GO:1902766

ILMN_1673305

ILMN_2313730

L25081_at

PH_hs_0010644

TC01006275.hg

g4885066_3p_s_at

Participates

as a component of

RHOC:GDP [cytosol] (Homo sapiens)

Other forms of this molecule

RHOC [plasma membrane]

RHOC [endoplasmic reticulum membrane]

Inferred To

RHOA [cytosol] (Saccharomyces cerevisiae)

RHOA [cytosol] (Schizosaccharomyces pombe)

Homologues of RHOC [cytosol] (Saccharomyces cerevisiae)

Homologues of RHOC [cytosol] (Schizosaccharomyces pombe)

RHOC [cytosol] (Bos taurus)

RHOC [cytosol] (Canis familiaris)

RHOC [cytosol] (Gallus gallus)

RHOC [cytosol] (Mus musculus)

RHOC [cytosol] (Saccharomyces cerevisiae)

RHOC [cytosol] (Schizosaccharomyces pombe)

RHOC [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_786886.1, NP_001036144.1, NP_001036143.1

OpenTargets

ENSG00000155366

ENSEMBL

ENST00000369637, ENST00000285735, ENST00000369638, ENSP00000345236, ENST00000339083, ENSG00000155366, ENSP00000358646, ENSP00000358647, ENSP00000358656, ENST00000369633, ENST00000369632, ENSP00000285735, ENSP00000358652, ENSP00000358651, ENST00000369642

HPA

ENSG00000155366-RHOC

GeneCards

RHOC

PRO

P08134

Pharos - Targets

P08134

GlyGen

P08134

PDB

2GCO, 2GCP, 2GCN, 1Z2C

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971)	0.725	5
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.643	4
UniProt:Q9Y4D1 DAAM1	1	DAAM1 [cytosol] (R-HSA-351052)	0.59	3
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.564	2
UniProt:Q9BST9 RTKN	1	RTKN [cytosol] (R-HSA-5666184)	0.527	2