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RHOC [plasma membrane]
Stable Identifier
R-HSA-194870
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RhoC
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RhoA,B,C:GDP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
LIM kinase phosphorylation by ROCK (Homo sapiens)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
ROCK activation by RHO (Homo sapiens)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RhoA,B,C:GDP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
ROCK activation by RHO (Homo sapiens)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
Activated FMNL3 binds G-actin (Homo sapiens)
RHOC:GTP:FMNL3 [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOC:GTP:FMNL3:G-actin [plasma membrane] (Homo sapiens)
RHOC:GTP:FMNL3 [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
FMNL2 binds RHOC:GTP (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOC:GTP:FMNL2 [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
FMNL3 binds RHOC:GTP (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOC:GTP:FMNL3 [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
LIM kinase phosphorylation by ROCK (Homo sapiens)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
Myosin phosphatase inactivation by ROCK (Homo sapiens)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
ROCK activation by RHO (Homo sapiens)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHO GTPases Activate Rhotekin and Rhophilins (Homo sapiens)
RTKN binds RHOA, RHOC or RHOB (Homo sapiens)
RHOA,B,C:GTP:RTKN [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA/B/C:GTP [plasma membrane] (Homo sapiens)
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
Activated CIT binds KIF14 and PRC1 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT:KIF14:PRC1 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
Activated CIT phosphorylates MRLCs (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
CIT-3 binds DLG4 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
GDIs block activation of RHOC (Homo sapiens)
RHOC:GDP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)
RHOC:GDP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC:GDP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOC binds effectors at the plasma membrane (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOC:GTP:RHOC effectors [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
RHOC translocates to the endoplasmic reticulum membrane (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
RHOC [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08134 RHOC
Gene Names
RHOC, ARH9, ARHC
Chain
chain:1-190, propeptide:191-193
Reference Genes
BioGPS Gene:389 RHOC
COSMIC (genes):RHOC RHOC
CTD Gene:389 RHOC
dbSNP Gene:389 RHOC
ENSEMBL:ENSG00000155366 RHOC
HGNC:669 RHOC
KEGG:hsa:389 RHOC
Monarch:389 RHOC
NCBI Gene:389 RHOC
OMIM:165380 RHOC
UCSC:P08134 RHOC
Reference Transcript
RefSeq:NM_175744.5 RHOC
RefSeq:NM_001042679.2 RHOC
RefSeq:NM_001042678.2 RHOC
Other Identifiers
11720791_a_at
11744352_x_at
11757578_x_at
1395_at
16690974
200885_PM_at
200885_at
2428404
2428406
2428407
2428408
2428409
2428410
2428411
2428412
2428413
2428414
2428415
2428416
2428417
2428418
2428419
2428420
2428421
2428422
2428424
2428426
2428427
2428428
389
61134_at
74701_at
7918593
89924_at
A_23_P12514
A_23_P406424
GE476399
GE61156
GO:0000166
GO:0000281
GO:0000910
GO:0003924
GO:0005515
GO:0005525
GO:0005634
GO:0005789
GO:0005829
GO:0005886
GO:0007015
GO:0007165
GO:0007264
GO:0016020
GO:0016477
GO:0016787
GO:0019901
GO:0030335
GO:0031334
GO:0032154
GO:0032420
GO:0032956
GO:0034330
GO:0043123
GO:0043297
GO:0044319
GO:0048870
GO:0051496
GO:0060193
GO:0070062
GO:1902766
HMNXSV003031671
Hs.105036.0.S1_3p_at
ILMN_1673305
ILMN_1799150
ILMN_2313730
L25081_at
PH_hs_0010644
PH_hs_0021942
TC01006275.hg
g4885066_3p_s_at
Participates
as a component of
RHOC:GDP [plasma membrane] (Homo sapiens)
RHOC:GTP [plasma membrane] (Homo sapiens)
as a member of
RHOA/B/C [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
RHOC [cytosol]
RHOC [endoplasmic reticulum membrane]
Inferred To
RHO2 [plasma membrane]
(Saccharomyces cerevisiae)
RHOC [plasma membrane]
(Bos taurus)
RHOC [plasma membrane]
(Canis familiaris)
RHOC [plasma membrane]
(Gallus gallus)
RHOC [plasma membrane]
(Sus scrofa)
rho4 [plasma membrane]
(Schizosaccharomyces pombe)
Homologues of RHOA [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of RHOA [plasma membrane]
(Schizosaccharomyces pombe)
RHO1 [plasma membrane]
(Saccharomyces cerevisiae)
rhoad [plasma membrane]
(Danio rerio)
Rhoc [plasma membrane]
(Mus musculus)
Rhoc [plasma membrane]
(Rattus norvegicus)
RHO3 [plasma membrane]
(Saccharomyces cerevisiae)
rho5 [plasma membrane]
(Schizosaccharomyces pombe)
rho2 [plasma membrane]
(Schizosaccharomyces pombe)
RHO4 [plasma membrane]
(Saccharomyces cerevisiae)
rho1 [plasma membrane]
(Schizosaccharomyces pombe)
rho3 [plasma membrane]
(Schizosaccharomyces pombe)
rhoc [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001036144.1
,
NP_786886.1
,
NP_001036143.1
OpenTargets
ENSG00000155366
ENSEMBL
ENSP00000358647
,
ENSP00000358646
,
ENST00000369642
,
ENSP00000358656
,
ENST00000369632
,
ENSG00000155366
,
ENST00000369633
,
ENSP00000358652
,
ENSP00000358651
,
ENSP00000285735
,
ENST00000285735
,
ENSP00000345236
,
ENST00000369638
,
ENST00000369637
,
ENST00000339083
HPA
ENSG00000155366-RHOC
GeneCards
RHOC
PRO
P08134
Pharos - Targets
P08134
GlyGen
P08134
PDB
1Z2C
,
2GCP
,
2GCO
,
2GCN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61586 RHOA
6
RHOA [plasma membrane]
(R-HSA-194510)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [cytosol]
(R-HSA-194866)
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
0.788
6
UniProt:P52306 RAP1GDS1
1
RAP1GDS1 [mitochondrial outer membrane]
(R-HSA-9693756)
0.725
5
UniProt:Q9Y4D1 DAAM1
1
DAAM1 [cytosol]
(R-HSA-351052)
0.688
4
UniProt:P52565 ARHGDIA
1
ARHGDIA [cytosol]
(R-HSA-194478)
0.564
2
UniProt:Q9BST9 RTKN
1
RTKN [cytosol]
(R-HSA-5666184)
0.527
2
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