4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one

Stable Identifier
R-HSA-193755
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
4-cholesten-7alpha,12alpha,24(S)-triol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one + NADP+
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4-cholesten-7alpha,12alpha,24(S)-triol-3-one and NADPH + H+ react to form 5beta-cholesten-7alpha,12alpha,24(S)-triol-3-one and NADP+. This reaction is catalyzed by AKR1D1 (3-oxo-5-beta-steroid 4-dehydrogenase). AKR1D1 is localized to the cytosol, and in the course of the reaction its steroid substrate moves from the endoplasmic reticulum membrane to the cytosol. It is unclear whether this translocation results simply from its increased hydrophilicity or is mediated by the enzyme or another transport protein (Russell 2003).

Literature References
PubMed ID Title Journal Year
7508385 Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme

Kondo, KH, Kai, MH, Setoguchi, Y, Eggertsen, G, Sjoblom, P, Setoguchi, T, Okuda, K, Bjorkhem, I

Eur J Biochem 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldo-keto reductase (NADP) activity of AKR1D1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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