Production of ceramide which can activate JNK and other targets

Stable Identifier
R-HSA-193706
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Production of ceramide which can activate JNK and other targets
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Sphingomyielinase promotes the conversion of sphingomyelin to ceramide. Ceramide can activate JNK and other targets. The molecular details of the p75NTR-activated ceramide signalling cascade are only partially understood.

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Output
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as an event of
Catalyst Activity

sphingomyelin phosphodiesterase activity of Active N-SMase:Mg2+ [plasma membrane]

Physical Entity
Active N-SMase:Mg2+ [plasma membrane] (Homo sapiens)
Activity
sphingomyelin phosphodiesterase activity (GO:0004767)
Inferred From
Production of ceramide which can activate JNK and other targets (Rattus norvegicus)
Cross References
Rhea
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-02-23)
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