Production of ceramide which can activate JNK and other targets

Stable Identifier
R-RNO-209562
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Production of ceramide which can activate JNK and other targets
Sphingomyielinase promotes the conversion of sphingomyelin to ceramide. Ceramide can activate JNK and other targets. The molecular details of the p75NTR-activated ceramide signalling cascade are only partially understood.
Literature References
PubMed ID Title Journal Year
8079174 Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor

Dobrowsky, RT, Werner, MH, Castellino, AM, Chao, MV, Hannun, YA

Science 1994
Participants
Input
Output
Catalyst Activity

sphingomyelin phosphodiesterase activity of Activated N-SMase (Mg cofactor) [plasma membrane]

Physical Entity
Activated N-SMase (Mg cofactor) [plasma membrane] (Rattus norvegicus)
Activity
sphingomyelin phosphodiesterase activity (GO:0004767)
Orthologous Events
Production of ceramide which can activate JNK and other targets (Homo sapiens)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-19)
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